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Título : Antitumor effect of oleic acid; mechanisms of action. A review
Otro título : Efecto antitumoral del ácido oleico; mecanismos de acción: revisión científica
Autor : Carrillo Pérez, Celia
Cavia Camarero, María del Mar
Alonso de la Torre, Sara
Publicado en: Nutrición Hospitalaria, 2012, v.27, n.6 (Noviembre-Diciembre), p. 1860-1865
Editorial : Grupo Aula Médica
Fecha de publicación : 2012
ISSN : 0212-1611
DOI: 10.3305/nh.2012.27.6.6010
Resumen : Introduction: The beneficial effects of oleic acid in cancer processes can no longer be doubted, but little is known about the mechanisms of action behind this phenomenon. Aim: The aim of the present review is to clarify whether oleic acid has an effect on important mechanisms related to the carcinogenic processes. Aim: The aim of the present review is to clarify whether oleic acid has an effect on important mechanisms related to the carcinogenic processes. Methods:We searched electronic databases and biblio - graphies of selected articles were inspected for further reference. We focused our research on two cellular transformations characterizing cancer development: proliferation and cell death or apoptosis. Results: Numerous studies have reported an inhibition in cell proliferation induced by oleic acid in different tumor cell lines. Herein, oleic acid could suppress the over-expression of HER2 (erbB-2), a well-characterized oncogene which plays a key role in the etiology, invasive progression and metastasis in several human cancers. In addition, oleic acid could play a role in intracellular calcium signaling pathways linked to the proliferation event. Regarding cell death, oleic acid has been shown to induce apoptosis in carcinoma cells. The mechanisms behind the apoptotic event induced by oleic acid could be related to an increase in intracellular ROS production or caspase 3 activity. Several unsaturated fatty acids have been reported to induce apoptosis through a release of calcium from intracellular stores. However, evidence regarding such a role in oleic acid is lacking. Conclusions:Oleic acid plays a role in the activation of different intracellular pathways involved in carcinoma cell development. Such a role could be the root of its antitumoral effects reported in clinical studies.
Palabras clave: Apoptosis
Oleic acid
Proliferation
Intracellular signaling
Ácido oleico
Proliferación celular
Señalización celular
Materia: Biología molecular
Biología molecular
Licencia: http://creativecommons.org/licenses/by/3.0/
URI : http://hdl.handle.net/10259.4/2522
Versión del editor: http://dx.doi.org/10.3305%2Fnh.2012.27.6.6010
Aparece en las colecciones: Artículos NUTRICION

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