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Título : An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media
Autor : Vallejos Calzada, Saúl
Estévez Bolívar, Pedro Antonio
Ibeas Cortes, Saturnino
García García, Félix Clemente
Serna Arenas, Felipe
García Pérez, José Miguel
Publicado en: Sensors, 2012, V. 12, n. 3, p. 2969-2982
Editorial : MDPI
Fecha de publicación : mar-2012
Resumen : The preparation of a fluorogenic sensory material for the detection of biomolecules is described. Strategic functionalisation and copolymerisation of a water insoluble organic sensory molecule with hydrophilic comonomers yielded a crosslinked, water-swellable, easy-to-manipulate solid system for water ‘‘dip-in’’ fluorogenic coenzyme A, cysteine, and glutathione detection by means of host-guest interactions. The sensory material was a membrane with gel-like behaviour, which exhibits a change in fluorescence behaviour upon swelling with a water solution of the target molecules. The membrane follows a “turn-on” pattern, which permits the titration of the abovementioned biomolecules. In this way, the water insoluble sensing motif can be exploited in aqueous media. The sensory motif within the membrane is a chemically anchored piperazinedione-derivative with a weakly bound Hg(II). The response is caused by the displacement of the cation from the membrane due to a stronger complexation with the biomolecules, thus releasing the fluorescent sensory moieties within the membrane
Palabras clave: sensory materials
chemosensor
fluorogenic sensor
biomolecules
sensing biomolecules
Licencia: http://creativecommons.org/licenses/by/3.0/
URI : http://hdl.handle.net/10259/4359
Versión del editor: http://dx.doi.org/10.3390/s120302969
Aparece en las colecciones: Artículos TERMOCIN
Artículos POLYMERS

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