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Título : Polymeric chemosensor for the detection and quantification of chloride in human sweat. Application to the diagnosis of cystic fibrosis
Autor : Vallejos Calzada, Saúl
Hernando Santa Cruz, Elsa
Trigo López, Miriam
García García, Félix Clemente
García Valverde, María
Iturbe, David .
Cabero, María Jesús .
Quesada Pato, Roberto
García Pérez, José Miguel
Publicado en: Journal of Materials Chemistry B. 2016, V. 6, n. 22, p. 3735-3741
Editorial : Royal Society of Chemistry
Fecha de publicación : jun-2018
Fecha de disponibilidad: 14-jun-2019
ISSN : 2050-750X
DOI: 10.1039/c8tb00682b
Resumen : We have developed a new extremely hydrophilic polymeric film suitable for the detection and quantification of chloride in human sweat directly on the skin. The film, or membrane, has chemically anchored 6-methoxyquinoline groups as chloride responsive fluorescent motifs. We have prepared the sensory material from a standard vinyl copolymer, by a convenient and easy solid-phase reaction. The sensory material has a water swelling percentage of 700%, facilitating an immediate detection of chloride, is reusable for at least 6 cycles and can be handled without care by unskilled persons. The initially high fluorescence of the material decreases in the presence of chloride, allowing the quantification of chloride concentration by using the colour definition of a digital picture or a fluorimeter. The suitability of the material to perform quantitative chloride analysis of human sweat by putting it in contact with the skin offers promise for its application in the sweat test used for the diagnosis of cystic fibrosis (CF).
URI : http://hdl.handle.net/10259/4815
Versión del editor: https://doi.org/10.1039/c8tb00682b
Aparece en las colecciones: Artículos BIOORG
Artículos POLYMERS

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