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Título : Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines
Autor : García Tojal, Javier
Gil García, Rubén
Fouz cuesta, Víctor Ivo
Madariaga, Gotzon .
Lezama, Luis .
Galletero, María S. .
Borrás, Joaquín .
Nollmann, Friederike I. .
García Girón, Carlos .
Alcaraz, Raquel .
Cavia Saiz, Mónica
Muñiz Rodríguez, Pilar
Palacios, Òscar .
Samper, Katia G. .
Rojo, Teófilo .
Publicado en: Journal of Inorganic Biochemistry. 2018, V. 180, p. 69–79
Editorial : Elsevier
Fecha de publicación : mar-2018
Fecha de disponibilidad: abr-2020
ISSN : 0162-0134
DOI: 10.1016/j.jinorgbio.2017.12.005
Resumen : Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands.
Palabras clave: Colon carcinoma
Copper
Molecular magnetism
Thiosemicarbazone
Materia: Química inorgánica
Chemistry, Inorganic
Aparato digestivo-Enfermedades
Digestive organs-Diseases
Licencia: http://creativecommons.org/licenses/by-nc-nd/4.0/
URI : http://hdl.handle.net/10259/4929
Versión del editor: https://doi.org/10.1016/j.jinorgbio.2017.12.005
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Artículos SINTORG

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