RT info:eu-repo/semantics/article
T1 Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses
A1 Muñoz Moreno, Raquel
A1 Martínez Romero, Carles
A1 Blanco Melo, Daniel
A1 Forst, Christian V.
A1 Nachbagauer, Raffael
A1 Benitez, Asiel Arturo
A1 Mena, Ignacio
A1 Aslam, Sadaf
A1 Balasubramaniam, Vinod
A1 Lee, Ilseob
A1 Panis, Maryline
A1 Ayllón Barasoain, Juan
A1 Sachs, David
A1 Park, Man-Seong
A1 Krammer, Florian
A1 tenOever, Benjamin R.
A1 García Sastre, Adolfo
K1 Influenza virus
K1 Orthomyxovirus
K1 NS1 evolution
K1 IFN response
K1 Innate immunity
K1 Barcoded library
K1 Medicina
K1 Medicine
K1 Salud
K1 Health
K1 Microbiología
K1 Microbiology
K1 Genética
K1 Genetics
K1 Enfermedades infecciosas
K1 Communicable diseases
AB Influenza A viruses (IAVs) have a remarkable tropism in their ability to circulate in both mammalian and avian species. The IAV NS1 protein is a multifunctional virulence factor that inhibits the type I interferon host response through a myriad of mechanisms. How NS1 has evolved to enable this remarkable property across species and its specific impact in the overall replication, pathogenicity, and host preference remain unknown. Here we analyze the NS1 evolutionary landscape and host tropism using a barcoded library of recombinant IAVs. Results show a surprisingly great variety of NS1 phenotypes according to their ability to replicate in different hosts. The IAV NS1 genes appear to have taken diverse and random evolutionary pathways within their multiple phylogenetic lineages. In summary, the high evolutionary plasticity of this viral protein underscores the ability of IAVs to adapt to multiple hosts and aids in our understanding of its global prevalence.
PB Cell Press
SN 2211-1247
YR 2019
FD 2019
LK http://hdl.handle.net/10259/7994
UL http://hdl.handle.net/10259/7994
LA eng
NO This research work was supported partially by CRIP (Center for Research on Influenza Pathogenesis), an NIH-NIAID-funded Center of Excellence for Influenza Research and Surveillance (CEIRS) (contract HHSN272201400008C), and by NIH-NIAID (grants U19AI117873 and U19AI135972). This research was also supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF), funded by the Ministry of Science and ICT of the Republic of Korea (NRF-2018M3A9H4056537 to M.-S.P., PI).
DS Repositorio Institucional de la Universidad de Burgos
RD 19-may-2024