RT info:eu-repo/semantics/article
T1 Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population
A1 Jiménez Jiménez, Félix Javier
A1 García Martín, Elena
A1 Alonso Navarro, Hortensia
A1 Martínez, Carmen
A1 Zurdo, Martín
A1 Turpín Fenoll, Laura
A1 Millán Pascual, Jorge
A1 Adeva Bartolomé, Teresa
A1 Cubo Delgado, Esther
A1 Navacerrada, Francisco
A1 Rojo Sebastián, Ana
A1 Rubio, Lluisa
A1 Ortega Cubero, Sara
A1 Pastor, Pau
A1 Calleja, Marisol
A1 Plaza Nieto, José Francisco
A1 Pilo de la Fuente, Belén
A1 Arroyo Solera, Margarita
A1 García Albea, Esteban
A1 Agúndez, José A. G.
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
AB Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS.We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay.The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively). Restless legs syndrome patients carrying the allelic variant rs731236G had an earlier age at onset, and those carrying the rs731236GG genotype had higher severity of RLS, although these data disappeared after multivariate analyses. None of the SNPs studied was related with the positivity of family history of RLS.These results suggest a modest, but significant association between VDR rs731236 SNP and the risk for RLS.
PB Wolters Kluwer Health
SN 0025-7974
YR 2015
FD 2015-11
LK http://hdl.handle.net/10259/8775
UL http://hdl.handle.net/10259/8775
LA eng
NO This work was supported in part by Grants PI12/00241, PI12/00324, and RETICS RD12/0013/0002 from Fondo de Investigacio´n Sanitaria, Instituto de Salud Carlos III, Madrid, Spain, and GR15026 from Junta de Extremadura, Me´rida, Spain, and PRIS10016 (Fundesalud, Me´rida,Spain), and by grants from the Spanish Ministry of Science and Innovation SAF2006-10126 (2006–2009) and SAF2010-22329-C02-01 (2011- 2013) to PP and by the ‘‘Unio´n Te´cnica de Empresas’’ (UTE) project FIMA to PP and project from the Centro de Investigaciones Me´dicas Aplicadas (CIMA), Spain. Partially funded with FEDER funds.
DS Repositorio Institucional de la Universidad de Burgos
RD 20-may-2024