https://hdl.handle.net/10259/9476 Wed, 06 May 2026 08:56:20 GMT 2026-05-06T08:56:20Z https://hdl.handle.net/10259/11462 Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study Escobedo-Monge, Marlene Fabiola; Barrado, Enrique; Parodi-Román, Joaquín; Escobedo Monge, María Antonieta; Torres-Hinojal, María; Marugán Miguelsanz, José Manuel Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population. Fri, 01 Oct 2021 00:00:00 GMT https://hdl.handle.net/10259/11462 2021-10-01T00:00:00Z https://hdl.handle.net/10259/11460 Long-Term Effects of the Application of Urban Waste Compost and Other Organic Amendments on Solanum tuberosum L. Escobedo Monge, María Antonieta; Aparicio Martínez, Santiago; Escobedo-Monge, Marlene Fabiola; Marugán Miguelsanz, José Manuel Background: In a Mediterranean agrosystem of low productivity, a study was carried out on the effects of municipal solid waste compost (MSWC) compared to other organic and inorganic amendments on the production, quality and yield of three potato varieties (Solanum tuberosum L.) and an advanced clone. Method: Simultaneously, the agronomic and nutritional parameters of the potato crop, the degree of bioavailability and the possible risks of heavy metal contamination were studied. Results: Two stages are observed in the yield and content of macro, micronutrients and heavy metals. The addition of all amendments and especially that of urban waste compost increased potato production and the content of macronutrients, micronutrients and heavy metals in the soils of all varieties, showing a progressive accumulation in tubers. Nevertheless, the performance is not maintained over time with a notable decrease during the second stage of its application. Conclusion: Highlighting the potato clone A7677 not only in its performance but also in the concentration of iron, zinc, copper, essential micronutrients for human consumption and especially for populations deficient in these trace elements. Thu, 01 Oct 2020 00:00:00 GMT https://hdl.handle.net/10259/11460 2020-10-01T00:00:00Z https://hdl.handle.net/10259/11459 Cineole – Decanoic acid hydrophobic natural Deep eutectic solvent for toluene absorption Trenzado, José Luis; Benito, Cristina; Escobedo Monge, María Antonieta; Atilhan, Mert; Aparicio Martínez, Santiago The hydrophobic deep eutectic solvent formed by the equimolar combination of natural compounds cineole and decanoic acid is studied as an archetypical compound for aromatics (toluene) solubilization/extraction purposes. The physicochemical properties of toluene solutions in the solvents are studied as a function of composition and temperature. The nature of intermolecular forces between toluene and solvent molecules is analyzed using a minimal clusters approach through quantum chemistry methods. Classical molecular dynamics simulation on toluene solution allowed us to infer nanoscopic behavior and structuring of the toluene mixtures using static and dynamic approaches. Likewise, the possible biological effects of the considered solvent are studied considering its effect on lipid bilayers as a model of plasma membranes using coarse-grained molecular dynamics methods. The reported results provide a multiscale combined experimental and computational characterization of hydrophobic Deep Eutectics as suitable solvents for aromatic hydrocarbons. Thu, 01 Jun 2023 00:00:00 GMT https://hdl.handle.net/10259/11459 2023-06-01T00:00:00Z https://hdl.handle.net/10259/11458 On the properties of water in betaine – based Deep Eutectic Solvents Alcalde García, Rafael T.; Aguilar Cuesta, Nuria; Escobedo Monge, María Antonieta; Trenzado, José Luis; Atilhan, Mert; Bol Arreba, Alfredo; Aparicio Martínez, Santiago Deep eutectic solvents have gained attention as environmentally friendly alternatives in various technological applications. Likewise, it is known the relevant effect of water on the physicochemical properties of Deep Eutectics, especially for hydrophilic ones. In this study, Betaine – based type III Deep Eutectic solvents (with ethylene glycol, fructose, malic acid or citric acid as Hydrogen Bond Donors) are considered and the properties and structuring of water in Deep Eutectic solutions (content lower than 20 %) were investigated considering volumetric properties, optical properties (refraction index), dynamic properties (viscosity, thermal conductivity, and electrical conductivity) as well as relevant characteristics for liquid phase nature such as polarizability and molecular packing. Viscosity measurements demonstrated a wide variation in viscosities, with water content playing a significant role, thus probing how water content largely affect dynamic properties of Deep Eutectics. Additionally, high water content led to improved thermal and electrical conductivity, particularly in mixtures containing citric acid and malic acid as Hydrogen Bond Donors. The polarizability decreased with increasing water content, and packing calculations indicated that the most voluminous molecules occupied interstitial voids. Our findings contribute to the understanding of water in Deep Eutectics solution, aiding their optimization for sustainable applications. Sat, 01 Jun 2024 00:00:00 GMT https://hdl.handle.net/10259/11458 2024-06-01T00:00:00Z