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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/9987

    Título
    Dietary tryptophan depletion alters the faecal bacterial community structure of compulsive drinker rats in schedule-induced polydipsia
    Autor
    Merchán Carrillo, Ana
    Pérez Fernández, Cristian AntonioAutoridad UBU
    López, María J.
    Moreno Casco, José Joaquín
    Moreno-Montoya, Margarita
    Sánchez Santed, Fernando
    Flores, Pilar
    Publicado en
    Physiology & Behavior. 2021, V. 233, 113356
    Editorial
    Elsevier
    Fecha de publicación
    2021-05
    ISSN
    0031-9384
    DOI
    10.1016/j.physbeh.2021.113356
    Resumen
    Rationale: Compulsive behaviour, present in different psychiatric disorders such as obsessive-compulsive disorder, schizophrenia and drug abuse, is associated with altered levels of serotonin (5-hydroxytryptamine, 5-HT). The gut microbiota regulates tryptophan (TRP) metabolism and may affect global 5-H synthesis in the enteric and central nervous systems, suggesting a possible involvement of gut microbiota in compulsive spectrum disorders. Objectives: The present study investigated whether chronic TRP depletion by diet alters the faecal bacterial community profiles of compulsive versus non-compulsive rats in schedule-induced polydipsia (SIP). Peripheral plasma 5-HT and brain-derived neurotrophic factor (BDNF) levels were evaluated. Methods: Wistar rats were selected as High Drinkers (HD) or Low Drinkers (LD) according to their SIP behaviour and were fed for 14 days with either a TRP-free diet (T-) or a TRP-supplemented diet (T+). The faecal bacterial community structure was investigated with 16S rRNA gene-targeted denaturing gradient gel electrophoresis (DGGE) fingerprinting analysis. Results: Compulsive HD rats showed a lower bacterial diversity than LD rats, irrespectively of the diet. The TRP-depleted HD rats, the only group increasing compulsive licking in SIP, showed a reduction of bacterial evenness and a highly functionally organized community compared with the other groups, indicating that this bacterial community is more fragile to external changes due to the dominance of a low number of species. The chronic TRP depletion by diet effectively reduced peripheral plasma 5-HT levels in both HD and LD rats, while plasma BDNF levels were not altered. Conclusions: These results highlight the possible implication of reduced microbial diversity in compulsive behaviour and the involvement of the serotonergic system in modulating the gut brain-axis in compulsive spectrum disorders.
    Palabras clave
    Compulsivity
    Schedule-induced polydipsia
    Gut microbiota
    Chronic tryptophan depletion
    PCR-DGGE
    Brain-derived neurotrophic factor
    Materia
    Triptófano
    Tryptophan
    Bacterias -- Metabolismo
    Microbial metabolism
    Psicología
    Psychology
    URI
    http://hdl.handle.net/10259/9987
    Versión del editor
    https://doi.org/10.1016/j.physbeh.2021.113356
    Aparece en las colecciones
    • Artículos Psicobiología
    Attribution-NonCommercial-NoDerivatives 4.0 Internacional
    Documento(s) sujeto(s) a una licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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    Merchan-pb_2021.pdf
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