2026-06-29T13:51:39Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/100392025-01-25T01:05:30Zcom_10259_6688com_10259_5086com_10259_2604col_10259_6689

Autoantibodies against type I IFNs in patients with life-threatening COVID-19 Bastard, Paul Rosen, Lindsey B. Zhang, Qian Michailidis, Eleftherios Hoffmann, Hans-Heinrich Zhang, Yu Dorgham, Karim Philippot, Quentin Rosain, Jérémie Béziat, Vivien Manry, Jérémy Shaw, Elana Haljasmägi, Liis Peterson, Pärt Lorenzo, Lazaro Bizien, Lucy Trouillet-Assant, Sophie Dobbs, Kerry de Jesus, Adriana Almeida Belot, Alexandre Kallaste, Anne Catherinot, Emilie Tandjaoui-Lambiotte, Yacine Le Pen, Jeremie Kerner, Gaspard Bigio, Benedetta Seeleuthner, Yoann Yang, Rui Bolze, Alexandre Spaan, András N. Delmonte, Ottavia M. Abers, Michael S. Aiuti, Alessandro Casari, Giorgio Lampasona, Vito Piemonti, Lorenzo Ciceri, Fabio Bilguvar, Kaya Lifton, Richard P. Vasse, Marc Smadja, David M. Migaud, Mélanie Hadjadj, Jérome Terrier, Benjamin Duffy, Darragh Quintana-Murci, Lluis van de Beek, Diederik Roussel, Lucie Vinh, Donald C. Tangye, Stuart G. Haerynck, Filomeen Dalmau, David Martinez-Picado, Javier Brodin, Petter Nussenzweig, Michel C. Boisson-Dupuis, Stéphanie Rodríguez-Gallego, Carlos Vogt, Guillaume Mogensen, Trine H. Oler, Andrew J. Gu, Jingwen Burbelo, Peter D. Cohen, Jeffrey I. Biondi, Andrea Bettini, Laura Rachele D'Angio, Mariella Bonfanti, Paolo Rossignol, Patrick Mayaux, Julien Rieux-Laucat, Frédéric Husebye, Eystein S. Fusco, Francesca Ursini, Matilde Valeria Imberti, Luisa Sottini, Alessandra Paghera, Simone Quiros-Roldan, Eugenia Rossi, Camillo Castagnoli, Riccardo Montagna, Daniela Licari, Amelia Marseglia, Gian Luigi Duval, Xavier Ghosn, Jade Tsang, John S. Goldbach-Mansky, Raphaela Kisand, Kai Lionakis, Michail S. Puel, Anne Zhang, Shen-Ying Holland, Steven M. Gorochov, Guy Jouanguy, Emmanuelle Rice, Charles M. Cobat, Aurélie Notarangelo, Luigi D. Abel, Laurent Su, Helen C. Casanova, Jean-Laurent Arias, Andrés Augusto Boisson, Bertrand Boucherit, Soraya Bustamante, Jacinta Chbihi, Marwa Chen, Jie Chrabieh, Maya Kochetkov, Tatiana Le Voyer, Tom Liu, Dana Nemirovskaya, Yelena Ogishi, Masato Papandrea, Dominick Patissier, Cécile Rapaport, Franck Roynard, Manon Vladikine, Natasha Woollett, Mark Zhang, Peng Kashyap, Anuj Ding, Li Bosticardo, Marita Wang, Qinlu Ochoa, Sebastian Liu, Hui Chauvin, Samuel D. Stack, Michael Koroleva, Galina Bansal, Neha Dalgard, Clifton L. Snow, Andrew L. Abad, Jorge Aguilera-Albesa, Sergio Akcan, Ozge Metin Darazam, Ilad Alavi Aldave, Juan C. Ramos, Miquel Alfonso Nadji, Seyed Alireza Alkan, Gulsum Allardet-Servent, Jerome Allende, Luis M. Alsina, Laia Alyanakian, Marie-Alexandra Amador-Borrero, Blanca Amoura, Zahir Antolí, Arnau Arslan, Sevket Assant, Sophie Auguet, Terese Azot, Axelle Bajolle, Fanny Baldolli, Aurélie Ballester, Maite Feldman, Hagit Baris Barrou, Benoit Beurton, Alexandra Bilbao, Agurtzane Blanchard-Rohner, Geraldine Blanco, Ignacio Blandinières, Adeline Blazquez-Gamero, Daniel Bloomfield, Marketa Bolivar-Prados, Mireia Borie, Raphael Bousfiha, Ahmed A. Bouvattier, Claire Boyarchuk, Oksana Bueno, Maria Rita P. Cáceres Agra, Juan José Calimli, Semra Capra, Ruggero Carrabba, Maria Casasnovas, Carlos Caseris, Marion Castelle, Martin Castelli, Francesco de Vera, Martín Castillo Castro, Mateus V. Chalumeau, Martin Charbit, Bruno Cheng, Matthew P. Clavé, Père Clotet, Bonaventura Codina, Anna Colkesen, Fatih Colkesen, Fatma Colobran, Roger Comarmond, Cloé Corsico, Angelo G. Darley, David Ross Dauby, Nicolas Dauger, Stéphane de Pontual, Loic Dehban, Amin Delplancq, Geoffroy Demoule, Alexandre Di Sabatino, Antonio Diehl, Jean-Luc Dobbelaere, Stephanie Durand, Sophie Eldars, Waleed Elgamal, Mohamed Elnagdy, Marwa H. Emiroglu, Melike Erdeniz, Emine Hafize Aytekin, Selma Erol Euvrard, Romain Evcen, Recep Fabio, Giovanna Faivre, Laurence Falck, Antonin Fartoukh, Muriel Faure, Morgane Arquero, Miguel Fernandez Flores, Carlos Francois, Bruno Fumadó, Victoria Solis, Blanca Garcia Gaussem, Pascale Gil-Herrera, Juana Gilardin, Laurent Alarcon, Monica Girona Girona-Alarcón, Mónica Goffard, Jean-Christophe Gok, Funda González-Montelongo, Rafaela Guerder, Antoine Gul, Yahya Guner, Sukru Nail Gut, Marta Hadjadj, Jérôme Halwani, Rabih Hammarström, Lennart Hatipoglu, Nevin Hernandez-Brito, Elisa Holanda-Peña, María Soledad Horcajada, Juan Pablo Hraiech, Sami Humbert, Linda Iglesias, Alejandro D. Íñigo-Campos, Antonio Jamme, Matthieu Arranz, María Jesús Jordan, Iolanda Kanat, Fikret Kapakli, Hasan Kara, Iskender Karbuz, Adem Yasar, Kadriye Kart Keles, Sevgi Demirkol, Yasemin Kendir Klocperk, Adam Król, Zbigniew J. Kuentz, Paul Kwan, Yat Wah M. Lagier, Jean-Christophe Lau, Yu-Lung Le Bourgeois, Fleur Leo, Yee-Sin Lopez, Rafael Leon Leung, Daniel Levin, Michael Levy, Michael Lévy, Romain Li, Zhi Linglart, Agnes Lorenzo-Salazar, José M. Louapre, Céline Lubetzki, Catherine Luyt, Charles-Edouard Lye, David C. Mansouri, Davood Marjani, Majid Pereira, Jesus Marquez Martin, Andrea Pueyo, David Martínez Marzana, Iciar Mathian, Alexis Matos, Larissa R. B. Matthews, Gail V. Mège, Jean-Louis Melki, Isabelle Meritet, Jean-François Metin, Ozge Meyts, Isabelle Mezidi, Mehdi Migeotte, Isabelle Millereux, Maude Mirault, Tristan Mircher, Clotilde Mirsaeidi, Mehdi Melián, Abián Montesdeoca Martinez, Antonio Morales Morange, Pierre Mordacq, Clémence Morelle, Guillaume Mouly, Stéphane Muñoz-Barrera, Adrián Nafati, Cyril Neves, João Farela Ng, Lisa F. P. Medina, Yeray Novoa Cuadros, Esmeralda Nuñez Ocejo-Vinyals, J. Gonzalo Orbak, Zerrin Oualha, Mehdi Özçelik, Tayfun Hammarström, Qiang Pan Parizot, Christophe Pascreau, Tiffany Paz-Artal, Estela de Diego, Rebeca Pérez Philippe, Aurélien Planas-Serra, Laura Ploin, Dominique Poissy, Julien Poncelet, Géraldine Pouletty, Marie Quentric, Paul Raoult, Didier Rebillat, Anne-Sophie Reisli, Ismail Ricart, Pilar Richard, Jean-Christophe Rivet, Nadia Rivière, Jacques G. Blanch, Gemma Rocamora Rodrigo, Carlos Rodriguez-Gallego, Carlos Rodríguez-Palmero, Agustí Romero, Carolina Soledad Rothenbuhler, Anya Rozenberg, Flore Ruiz del Prado, Maria Yolanda Riera, Joan Sabater Sanchez, Oliver Sánchez-Ramón, Silvia Schluter, Agatha Schmidt, Matthieu Schweitzer, Cyril E. Scolari, Francesco Sediva, Anna Seijo, Luis M. Sene, Damien Senoglu, Sevtap Seppänen, Mikko R. J. Ilovich, Alex Serra Shahrooei, Mohammad Smadja, David Sobh, Ali Moreno, Xavier Solanich Solé-Violán, Jordi Soler, Catherine Soler-Palacín, Pere Stepanovskiy, Yuri Stoclin, Annabelle Taccone, Fabio Taupin, Jean-Luc Tavernier, Simon J. Thumerelle, Caroline Tomasoni, Gabriele Toubiana, Julie Alvarez, Josep Trenado Troya, Jesús Tucci, Alessandra Uzunhan, Yurdagul Vabres, Pierre Valencia Ramos, Juan Van Den Rym, Ana Maria Vandernoot, Isabelle Vatansev, Hulya Vélez-Santamaria, Valentina Viel, Sébastien Vilain, Cédric Vilaire, Marie E. Vincent, Audrey Voiriot, Guillaume Vuotto, Fanny Yosunkaya, Alper Young, Barnaby E. Yucel, Fatih Zannad, Faiez Zatz, Mayana Foti, Giuseppe Bellani, Giacomo Citerio, Giuseppe Contro, Ernesto Pesci, Alberto Valsecchi, Maria Grazia Cazzaniga, Marina Bole-Feysot, Christine Lyonnet, Stanislas Masson, Cécile Nitschke, Patrick Pouliet, Aurore Schmitt, Yoann Tores, Frederic Zarhrate, Mohammed Andrejak, Claire Angoulvant, François Bachelet, Delphine Basmaci, Romain Behillil, Sylvie Beluze, Marine Benkerrou, Dehbia Bhavsar, Krishna Bompart, François Bouadma, Lila Bouscambert, Maude Caralp, Mireille Cervantes-Gonzalez, Minerva Chair, Anissa Coelho, Alexandra Couffignal, Camille Couffin-Cadiergues, Sandrine D’ortenzio, Eric Da Silveira, Charlene Debray, Marie-Pierre Deplanque, Dominique Descamps, Diane Desvallées, Mathilde Diallo, Alpha Diouf, Alphonsine Dorival, Céline Dubos, François Eloy, Philippine Enouf, Vincent V. E. Esperou, Hélène Esposito-Farese, Marina Etienne, Manuel Ettalhaoui, Nadia Gault, Nathalie Gaymard, Alexandre Gigante, Tristan Gorenne, Isabelle Guedj, Jérémie Hoctin, Alexandre Hoffmann, Isabelle Jaafoura, Salma Kafif, Ouifiya Kaguelidou, Florentia Kali, Sabina Khalil, Antoine Khan, Coralie Laouénan, Cédric Laribi, Samira Le, Minh Le Hingrat, Quentin Le Mestre, Soizic Le Nagard, Hervé Lescure, François-Xavier Lévy, Yves Levy-Marchal, Claire Lina, Bruno Lingas, Guillaume Lucet, Jean Christophe Malvy, Denis Mambert, Marina Mentré, France Mercier, Noémie Meziane, Amina Mouquet, Hugo Mullaert, Jimmy Neant, Nadège Noret, Marion Pages, Justine Papadopoulos, Aurélie Paul, Christelle Peiffer-Smadja, Nathan Petrov-Sanchez, Ventzislava Peytavin, Gilles Picone, Olivier Puéchal, Oriane Rosa-Calatrava, Manuel Rossignol, Bénédicte Roy, Carine Schneider, Marion Semaille, Caroline Mohammed, Nassima Si Tagherset, Lysa Tardivon, Coralie Tellier, Marie-Capucine Téoulé, François Terrier, Olivier Timsit, Jean-François Treoux, Théo Tual, Christelle Tubiana, Sarah van der Werf, Sylvie Vanel, Noémie Veislinger, Aurélie Visseaux, Benoit Wiedemann, Aurélie Yazdanpanah, Yazdan Alcover, Andres Aschard, Hugues Astrom, Kalla Bousso, Philippe Bruhns, Pierre Cumano, Ana Demangel, Caroline Deriano, Ludovic Di Santo, James Dromer, Françoise Eberl, Gérard Enninga, Jost Fellay, Jacques Gomperts-Boneca, Ivo Hasan, Milena Hercberg, Serge Lantz, Olivier Patin, Etienne Pellegrini, Sandra Pol, Stanislas Rausell, Antonio Rogge, Lars Sakuntabhai, Anavaj Schwartz, Olivier Schwikowski, Benno Shorte, Spencer Tangy, Frédéric Toubert, Antoine Touvier, Mathilde Ungeheuer, Marie-Noëlle Albert, Matthew L. Alavoine, Loubna Amat, Karine K. A. Bielicki, Julia Bruijning, Patricia Burdet, Charles Caumes, Eric Charpentier, Charlotte Coignard, Bruno Costa, Yolande Damond, Florence Dechanet, Aline Delmas, Christelle Ecobichon, Jean-Luc Enouf, Vincent Espérou, Hélène Frezouls, Wahiba Houhou, Nadhira Ilic-Habensus, Emila Kikoine, John Lebeaux, David Leclercq, Anne Lehacaut, Jonathan Letrou, Sophie Lucet, Jean-Christophe Manchon, Pauline Mandic, Milica Meghadecha, Mohamed Motiejunaite, Justina Nouroudine, Mariama Piquard, Valentine Postolache, Andreea Quintin, Caroline Rexach, Jade Roufai, Layidé Terzian, Zaven Thy, Michael Vignali, Valérie van Agtmael, Michiel Algera, Anna Geke van Baarle, Frank Bax, Diane Beudel, Martijn Bogaard, Harm Jan Bomers, Marije Bos, Lieuwe Botta, Michela de Brabander, Justin Bree, Godelieve Brouwer, Matthijs C. de Bruin, Sanne Bugiani, Marianna Bulle, Esther Chouchane, Osoul Cloherty, Alex Elbers, Paul Fleuren, Lucas Geerlings, Suzanne Geerts, Bart Geijtenbeek, Theo Girbes, Armand Goorhuis, Bram Grobusch, Martin P. Hafkamp, Florianne Hagens, Laura Hamann, Jorg Harris, Vanessa Hemke, Robert Hermans, Sabine M. Heunks, Leo Hollmann, Markus W. Horn, Janneke Hovius, Joppe W. de Jong, Menno D. Koning, Rutger van Mourik, Niels Nellen, Jeaninne Paulus, Frederique Peters, Edgar van der Poll, Tom Preckel, Benedikt Prins, Jan M. Raasveld, Jorinde Reijnders, Tom Schinkel, Michiel Schultz, Marcus J. Schuurman, Alex Sigaloff, Kim Smit, Marry Stijnis, Cornelis S. Stilma, Willemke Teunissen, Charlotte Thoral, Patrick Tsonas, Anissa van der Valk, Marc Veelo, Denise Vlaar, Alexander P. J. de Vries, Heder van Vugt, Michèle Wiersinga, W. Joost Wouters, Dorien Zwinderman, A. H. (Koos) Al Muhsen, Saleh Al-Mulla, Fahd Anderson, Mark S. Bogunovic, Dusan Bondarenko, Anastasiia Bryceson, Yenan Bustamante, Carlos D. Butte, Manish Chakravorty, Samya Christodoulou, John Cirulli, Elizabeth Condino-Neto, Antonio Cooper, Megan A. DeRisi, Joseph L. Desai, Murkesh Drolet, Beth A. Espinosa, Sara Franco, Jose Luis Gregersen, Peter K. Hagin, David Heath, Jim Henrickson, Sarah E. Hsieh, Elena Imai, Kohsuke Itan, Yuval Karamitros, Timokratis Ku, Cheng-Lung Ling, Yun Lucas, Carrie L. Maniatis, Tom Mansouri, Davoud Marodi, Laszlo Milner, Joshua D. Mironska, Kristina Mogensen, Trine Morio, Tomohiro Novelli, Giuseppe Novelli, Antonio O'Farrelly, Cliona Okada, Satoshi Ozcelik, Tayfun de Diego, Rebeca Perez Planas, Anna M. Prando, Carolina Pujol, Aurora Renia, Laurent Renieri, Alessandra Sancho-Shimizu, Vanessa Sankaran, Vijay Barrett, Kelly Schiabor Shahrooei, Mohammed Snow, Andrew Tangye, Stuart Turvey, Stuart Uddin, Furkan Uddin, Mohammed J. Vazquez, Sara E. von Bernuth, Horst Washington, Nicole Zawadzki, Pawel Interindividual clinical vari-ability is vast in humans infected withsevere acute respiratory syndrome corona-virus 2 (SARS-CoV-2), ranging from silent in-fection to rapid death. Three risk factors forlife-threatening coronavirus disease 2019(COVID-19) pneumonia have been identified—being male, being elderly, or having othermedical conditions—but these risk factorscannot explain why critical disease remainsrelatively rare in any given epidemiologicalgroup. Given the rising toll of the COVID-19pandemic in terms of morbidity and mortality,understanding the causes and mechanisms oflife-threatening COVID-19 is crucial. 2025-01-24T12:00:42Z 2025-01-24T12:00:42Z 2020-09 info:eu-repo/semantics/article 0036-8075 http://hdl.handle.net/10259/10039 10.1126/science.abd4585 1095-9203 spa Science. 2020, V. 370, n. 6515 https://doi.org/10.1126/science.abd4585 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional American Association for the Advancement of Science