2026-06-06T03:14:04Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/100502025-01-30T01:05:31Zcom_10259_3844com_10259_5086com_10259_2604col_10259_3845

Wiloch, Magdalena Z. e916eee0-5877-4658-8421-2e3c6f0cb61d Pérez Estébanez, Martín 777 600 0000-0003-1510-5422 Baran, Natalia 996b4b42-448d-4ddd-8894-d37f1afef206 Heras Vidaurre, Aránzazu 273 600 0000-0002-5068-2164 Jönsson-Niedziółka, Martin 71cd8dc1-3591-4d2c-87d1-7cae78276c32 Colina Santamaría, Álvaro 122 600 0000-0003-0339-356X 2025-01-29T07:34:18Z 2025-01-29T07:34:18Z 2025 1567-5394 http://hdl.handle.net/10259/10050 10.1016/j.bioelechem.2024.108814 1878-562X Alzheimer’s Disease (AD), reported for the first time in 1906, is a common disease that remains incurable to this day. In the past, a family of treatments using Cu(II) chelators failed during clinical trials, evidencing the importance of pre-clinical studies. In this work, we performed electrochemical characterisation of TDMQ20, a new potential drug against AD, using electrochemistry and spectroelectrochemistry. On the basis of voltammetry, we determined that TDMQ20 undergoes a two-step irreversible oxidation process and a one-step irreversible reduction process. Both oxidation and reduction reactions are pH-sensitive. Bidimensional UV–Vis spectroelectrochemistry (UV–Vis-SEC) allowed us to confirm that oxidation of TDMQ20 can occur both on the aliphatic chain and on the aromatic ring. The results expand the knowledge of the TDMQ20 redox activity in the human body which is important from the point of view of the toxicity of the proposed therapy. This work has been financially supported by the National Science Centre Poland within the Sonatina project 2021/40/C/ST4/00090. application/pdf eng Elsevier Bioelectrochemistry. 2025, V. 161, 108814 https://doi.org/10.1016/j.bioelechem.2024.108814 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Voltammetry TDMQ20 Spectroelectrochemistry Alzheimer’s disease Química analítica Electroquímica Chemistry, Analytic Electrochemistry Spectroelectrochemical studies of TDMQ20: A potential drug against Alzheimer’s disease info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bioelectrochemistry 161 108814 THUMBNAIL Wiloch-bioelectrochemistry_2025.pdf.jpg Wiloch-bioelectrochemistry_2025.pdf.jpg IM Thumbnail image/jpeg 4986 https://riubu.ubu.es/bitstream/10259/10050/4/Wiloch-bioelectrochemistry_2025.pdf.jpg 2ed7407cdbbd1deddd400ca468dbf639 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/10050/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/10050/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Wiloch-bioelectrochemistry_2025.pdf Wiloch-bioelectrochemistry_2025.pdf application/pdf 1965124 https://riubu.ubu.es/bitstream/10259/10050/1/Wiloch-bioelectrochemistry_2025.pdf 85e191de75ecc6a82a5570de868b34f7 MD5 1 10259/10050 oai:riubu.ubu.es:10259/10050 2025-01-30 02:05:31.782 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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