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oai:riubu.ubu.es:10259/101212025-02-01T01:05:43Zcom_10259_6168com_10259_5086com_10259_2604col_10259_6169

2025-01-31T11:56:32Z urn:hdl:10259/10121 Appended Aromatic Moieties Determine the Cytotoxicity of Neutral Cyclometalated Platinum(II) Complexes Derived from 2-(2-Pyridyl)benzimidazole Vaquero Gutiérrez, Mónica Busto Vázquez, Natalia Fernández Pampín, Natalia Espino Ordóñez, Gustavo García Ruiz, Begoña Cyclometalated Pt(II) complexes Axial chirality Pyridylbenzimidazole DNA Binding Cytotoxicity A new family of neutral chiral cyclometalated platinum(II) complexes with formula [Pt(κ2-(C^N))Cl(κ1-(L))], where (C^N) = 2-phenylpyridinate and (L) = 2-(2-pyridyl)benzimidazole (L1) or (N-(CH2)-Ar-(2-(2-pyridyl)benzimidazole) ligands; (Ar = phenyl (L2), naphthyl (L3), pyrenyl (L4)), have been synthesized and completely characterized. The unexpected κ1 coordination mode of the 2-(2-pyridyl)benzimidazole-derived ligands has been confirmed by spectroscopic techniques and X-ray diffraction. The aromatic moieties on the ligands in the new platinum(II) complexes have a remarkable influence on the cytotoxicity and in the binding mode to DNA. [Pt-L1]–[Pt-L4] complexes internalized more than cisplatin in the SW480 cancer cells even though only [Pt-L1] and [Pt-L2] display high cytotoxicity. 1H NMR and 13P{1H}NMR pointed out that [Pt-L1] and [Pt-L2] complexes bind covalently to dGMP, while the electrophoresis assays and CD experiments indicate that only [Pt-L2] is able to covalently interact with DNA, inducing the same conformational changes in the plasmid DNA as cisplatin. Although the complex [Pt-L4] intercalates into DNA, probably through the pyrenyl moiety, no biological activity is observed. 2025-01-31T11:56:32Z 2025-01-31T11:56:32Z 2020-03 info:eu-repo/semantics/article 0020-1669 http://hdl.handle.net/10259/10121 10.1021/acs.inorgchem.0c00219 1520-510X eng Inorganic Chemistry. 2020, V. 59, n. 7, p. 4961–4971 https://doi.org/10.1021/acs.inorgchem.0c00219 info:eu-repo/semantics/openAccess American Chemical Society