2026-04-17T11:44:26Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/101632026-01-31T23:42:24Zcom_10259_4354com_10259_5086com_10259_2604col_10259_4355

Self-assembling Depsipeptides on Aggregation-Induced Emission Luminogens: A New Way to Create Programmable Nanovesicles and Soft Nanocarriers Hernando Muñoz, Carla Revilla Cuesta, Andrea Abajo Cuadrado, Irene Andreini, Camilla Torroba Pérez, Tomás Busto Vázquez, Natalia Fernández Zoppino, Darío Perdomo Hernández, Germán M. Acosta, Gerardo Royo, Miriam Gutiérrez Reguera, Javier Spinello, Angelo Barone, Giampaolo Black, Dominic Pal, Robert Fluorescent materials Aggregation induced emission materials Active transport Nanoencapsulation Programmed cytotoxity Química orgánica Nanotecnología Química física Chemistry, Organic Nanotechnology Chemistry, Physical and theoretical We introduce the proof of concept of a newmethodology to produce robust hollow nanovesicles stable inwater or mixtures of water and organic solvents. The bottom-upproduced nanovesicles are formed by the self-assembly ofdepsipeptide chains of natural origin combined with newaggregation-induced emission luminogens that function as constitu-tional vesicle-forming moieties and fluorescent indicators of thestructure of the nanovesicle. The newly formed nanovesicles arerobust enough to be used to carry large molecules such asphysiological peptides without losing their structural characteristics,acting as programmable nanocarrier systems within living cells asTrojan horse systems, constituting a new approach to activetransport and nanoencapsulation. This research was funded by the Ministerio de Ciencia,Innovación y Universidades of Spain (Grants PDC2022−133955-I00 and PID2022−142318NB-I00). C.H.-M. thanksthe Secretaría General de Universidades of Spain for an FPU21/01473 Grant. 2025-02-04T13:45:20Z 2025-02-04T13:45:20Z 2025-01 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 1944-8244 http://hdl.handle.net/10259/10163 10.1021/acsami.4c19123 1944-8252 eng ACS Applied Materials & Interfaces. 2025 https://doi.org/10.1021/acsami.4c19123 info:eu-repo/semantics/openAccess application/pdf American Chemical Society https://riubu.ubu.es/bitstream/10259/10163/3/Hernando-ACSam%26i_2025.pdf.jpg Hispana TEXT http://rightsstatements.org/vocab/CNE/1.0/ RIUBU. Repositorio Institucional de la Universidad de Burgos http://hdl.handle.net/10259/10163