2026-04-17T11:45:08Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/101632026-01-31T23:42:24Zcom_10259_4354com_10259_5086com_10259_2604col_10259_4355

Hernando Muñoz, Carla 771 600 Revilla Cuesta, Andrea 778 600 0000-0002-8045-3602 Abajo Cuadrado, Irene 760 600 Andreini, Camilla de3a9e67-4d15-4750-8d25-e207f95280ea 600 Torroba Pérez, Tomás 554 600 0000-0002-5018-4173 Busto Vázquez, Natalia 83 600 0000-0001-9637-1209 Fernández Zoppino, Darío 625 600 0000-0002-9763-7328 Perdomo Hernández, Germán M. 433 600 0000-0003-0348-4082 Acosta, Gerardo 19cfefc3-60d2-4fac-8fd4-581ada2f844b 600 Royo, Miriam 06f1635a-14f2-4d76-9148-0f5537e8ed5e 600 Gutiérrez Reguera, Javier a2c2001d-debc-49c7-910b-a36f14352198 600 Spinello, Angelo b8ec6fe6-913d-4ab1-87b6-0169c5d4f08b 600 Barone, Giampaolo 2502c306-a514-4e96-9cd8-7a3b547ae347 600 Black, Dominic 47762f81-b141-44d0-8da3-93ec2478d41a 600 Pal, Robert efd0470a-71f4-48be-93da-62370f74709a 600 2025-02-04T13:45:20Z 2025-02-04T13:45:20Z 2025-01 1944-8244 http://hdl.handle.net/10259/10163 10.1021/acsami.4c19123 1944-8252 We introduce the proof of concept of a newmethodology to produce robust hollow nanovesicles stable inwater or mixtures of water and organic solvents. The bottom-upproduced nanovesicles are formed by the self-assembly ofdepsipeptide chains of natural origin combined with newaggregation-induced emission luminogens that function as constitu-tional vesicle-forming moieties and fluorescent indicators of thestructure of the nanovesicle. The newly formed nanovesicles arerobust enough to be used to carry large molecules such asphysiological peptides without losing their structural characteristics,acting as programmable nanocarrier systems within living cells asTrojan horse systems, constituting a new approach to activetransport and nanoencapsulation. This research was funded by the Ministerio de Ciencia,Innovación y Universidades of Spain (Grants PDC2022−133955-I00 and PID2022−142318NB-I00). C.H.-M. thanksthe Secretaría General de Universidades of Spain for an FPU21/01473 Grant. application/pdf eng American Chemical Society ACS Applied Materials & Interfaces. 2025 https://doi.org/10.1021/acsami.4c19123 Fluorescent materials Aggregation induced emission materials Active transport Nanoencapsulation Programmed cytotoxity Química orgánica Nanotecnología Química física Chemistry, Organic Nanotechnology Chemistry, Physical and theoretical Self-assembling Depsipeptides on Aggregation-Induced Emission Luminogens: A New Way to Create Programmable Nanovesicles and Soft Nanocarriers info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/openAccess ACS Applied Materials & Interfaces THUMBNAIL Hernando-ACSam&i_2025.pdf.jpg Hernando-ACSam&i_2025.pdf.jpg IM Thumbnail image/jpeg 4031 https://riubu.ubu.es/bitstream/10259/10163/3/Hernando-ACSam%26i_2025.pdf.jpg a790733d7bc37e429b8ba7b9171d1ac3 MD5 3 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/10163/2/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 2 ORIGINAL Hernando-ACSam&i_2025.pdf Hernando-ACSam&i_2025.pdf application/pdf 1954911 https://riubu.ubu.es/bitstream/10259/10163/1/Hernando-ACSam%26i_2025.pdf 080082bb8485885f89f51ee9342778ac MD5 1 10259/10163 oai:riubu.ubu.es:10259/10163 2026-02-01 00:42:24.259 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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