2026-04-17T05:42:35Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/101942025-07-28T11:51:01Zcom_10259_3844com_10259_5086com_10259_2604col_10259_3845
Romay García, Luis
fb36536c-35b3-4eda-a01f-210b1c317623
600
Pérez Estébanez, Martín
777
600
0000-0003-1510-5422
Heras Vidaurre, Aránzazu
273
600
0000-0002-5068-2164
Colina Santamaría, Álvaro
122
600
0000-0003-0339-356X
2025-02-10T09:21:13Z
2025-02-10T09:21:13Z
2025-01
0026-265X
http://hdl.handle.net/10259/10194
10.1016/j.microc.2024.112551
Quantitative methods using surface-enhanced Raman scattering (SERS) for analysis in complex matrices are very
attractive due to the high sensitivity and selectivity of this technique. In this work, a novel time-resolved elec
trochemical surface-enhanced Raman scattering (TR-EC-SERS) analytical method has been developed for the
determination of nicotine in e-liquids of electronic cigarettes. One of the main challenges of SERS is its inherent
lack of reproducibility. Here, this limitation was mitigated by employing an electrochemical pre-treatment step
to generate a homogeneous distribution of silver nanoparticles (Ag-NPs) on a silver screen-printed electrode. The
enhanced Raman scattering induced by the Ag-NPs enabled the detection of nicotine at nanomolar levels. The
high sensitivity of the method allowed the quantitative analysis of diluted e-liquid samples, mitigating potential
interferences from other components present in these complex matrices. Moreover, TR-EC-SERS, coupled with
parallel factor analysis (PARAFAC), demonstrated the capability of trilinear spectroelectrochemistry data not
only to detect nicotine but also to identify potential interfering compounds without prior knowledge of their
spectral signatures. This multivariate approach offers significant potential for the detection of outliers in complex
samples.
Ministerio de Ciencia e Innovacion ´ and Agencia Estatal de Investigacion ´ (MCIN/AEI/10.13039/501100011033, PID2020-113154RBC21, PID2023-149188OB-I00) and FEDER, UE, Junta de Castilla y Leon ´ and European Regional Development Fund (Grant number: BU036P23), Ministerio de Ciencia, Innovacion ´ y Universidades (RED2022-134120-T) are gratefully acknowledged for funding this work. L.R. acknowledges Ministerio de Ciencia e Innovacion ´ and Agencia Estatal de Investigacion ´ (MCIN/AEI/ 10.13039/ 501100011033, PIS2020-113154 GB-C21) for the predoctoral contract
application/pdf
eng
Elsevier
Microchemical Journal. 2025, V. 208, p. 112551
https://doi.org/10.1016/j.microc.2024.112551
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2017-2020/PID2020-113154RB-C21/ES/APLICACION DE NUEVOS MATERIALES Y DISPOSITIVOS PARA EC-SERS Y EC-SOERS/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PID2023-149188OB-I00/ES/MAS ALLA DE LA AMPLIFICACION DE LA DISPERSION RAMAN POR LA SUPERFICIE: MEJORA ELECTROQUIMICA DE LA SEÑAL RAMAN CON FINES ANALITICOS/
info:eu-repo/grantAgreement/Junta de Castilla y León//BU036P23//Desarrollo de técnicas analíticas in-situ y en condiciones operando para el estudio de electrocatalizadores para la conversión electroquímica de nitrato de amoniaco/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/RED2022-134120-T/ES/RED DE SENSORES Y BIOSENSORES ELECTROQUIMICOS: RETOS ANTE LA TRANSFORMACION DIGITAL E INDUSTRIAL/
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
SERS
Spectroelectrochemistry
PARAFAC
Nicotine
E-liquid
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Microchemical Journal
208
112551
THUMBNAIL
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ORIGINAL
Romay-mj_2025.pdf
Romay-mj_2025.pdf
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10259/10194
oai:riubu.ubu.es:10259/10194
2025-07-28 13:51:01.26
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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