2026-05-12T02:56:04Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/105022025-05-28T00:05:24Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594
Gómez Gil, Sara
911
600
0000-0001-6556-5844
Cases, Nuria
6f53025a-64cc-4ef5-b1fa-18c897f91b91
600
Hernández Ruiz, Raquel
277
600
0000-0001-5018-0845
Rubio Presa, Rubén
493
600
0000-0002-9938-2058
Suárez Pantiga, Samuel
544
600
0000-0002-4249-7807
Pedrosa Sáez, María de los Remedios
422
600
0000-0001-7083-8093
Sanz Díez, Roberto
531
600
0000-0003-2830-0892
2025-05-27T12:23:29Z
2025-05-27T12:23:29Z
2024-03
1434-193X
http://hdl.handle.net/10259/10502
10.1002/ejoc.202400145
1099-0690
We report the efficient, sustainable one-pot synthesis of a wide variety of N-polyheterocycles, such as imidazo-quinolines and quinoxalines, and furoquinolines, from easily available nitroaromatics and glycols via a molybdenum catalytic domino reduction-imine formation-intramolecular cyclization-oxidation sequence. It is worth highlighting that the recycling and incorporation of the waste carbonyl byproduct, generated in the reduction step, into the final compound is realized. In addition, the overall efficiency and atom economy of the process are further improved owing to the participation of one reaction intermediate as reductant that allows lowering the amount of external reducing agent employed.
We gratefully acknowledge Ministerio de Ciencia e Innovación (PID2020-115789GB−C21/AEI/10.13039/501100011033), and Junta de Castilla y León and FEDER (BU028P23) for financial support. S.G.-G. thanks Ministerio de Educación for a FPU predoctoral contract. S.S.-P. thanks a Ramón y Cajal (RYC2021-031533-I) contract funded by MCIN/AEI/10.13039/501100011033 and European Union “NextGenerationEU”/PRTR.
application/pdf
eng
Wiley
European Journal of Organic Chemistry. 2024, V. 27, n. 18, p. e202400145
https://doi.org/10.1002/ejoc.202400145
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
Química
Chemistry
Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
European Journal of Organic Chemistry
27
18
e202400145
THUMBNAIL
Gómez-ejooc_2024.pdf.jpg
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Gómez-ejooc_2024.pdf
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10259/10502
oai:riubu.ubu.es:10259/10502
2025-05-28 02:05:24.451
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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