2026-04-22T16:43:04Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/105052025-05-29T00:05:14Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

Molybdenum‐Catalyzed Direct Synthesis of Pyrroles from Nitroarenes with Glycols as Reductants Gómez Gil, Sara Suárez Pantiga, Samuel Pedrosa Sáez, María de los Remedios Sanz Díez, Roberto Nitroarenes Pyrroles Reduction Molybdenum Glycols Química Química orgánica Chemistry Chemistry, Organic A molybdenum-catalyzed synthesis of N-(hetero)aryl pyrroles directly from inexpensive and commonly available (hetero)nitroarenes via reduction with pinacol and annulation with 1,4-dicarbonyls or cyclobutane-1,2-diols has been described. The process does not require an inert atmosphere and tolerates the presence of air and water. This non-noble catalytic system shows high chemoselectivity, allowing a diverse range of potentially reducible functional groups such as alkynes, alkenes, halogens, cyano, and carbonyls. Moreover, this strategy enables the reuse of a waste byproduct as reactant, facilitating the formation of challenging 1,4-dicarbonyls from accessible cyclobutane-1,2-diols used as reducing agents. We acknowledge the financial support from Ministerio de Ciencia, Innovación y Universidades (PID2020-115789GB-C21/AEI/10.1039/501100011033 and PDC2021-115789GB-C21), and Junta de Castilla y León and FEDER (BU028P23). S.G.-G. thanks Ministerio de Ciencia, Innovación y Universidades for a FPU predoctoral contract. S.S.-P. thanks Ministerio de Ciencia, Innovación y Universidades and “NextGenerationEU”/PRTR EU for a Ramón y Cajal contract (RYC2021-031533-I). 2025-05-28T07:16:54Z 2025-05-28T07:16:54Z 2024-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1615-4150 http://hdl.handle.net/10259/10505 10.1002/adsc.202401170 1615-4169 eng Advanced Synthesis & Catalysis. 2024, V. 367, n. 4, p. e202401170 https://doi.org/10.1002/adsc.202401170 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf Wiley