2026-04-21T14:00:05Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/105072025-05-29T00:05:20Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

Feberero García, Claudia Virumbrales Ortiz, Cintia Sedano Labrador, Carlos Renedo Peña, Lorena Suárez Pantiga, Samuel Sanz Díez, Roberto 2022-01 A straightforward and transition metal-free one-pot protocol to synthesize halobenzo[b]furans has been developed employing simple and easily available starting materials such as O-aryl carbamates and alkynylsulfones. The fine-tuning of the different steps involved was key to achieving a successful one-pot procedure. Initially, a directed ortho-lithiation process, which uses the carbamate as the directed metalation group, was crucial in providing access to O-2-alkynylaryl N,N-diethyl carbamates by a direct alkynylation of the o-lithiated carbamate, with arylsulfonylalkynes as electrophilic reagents. Cyclization of the generated o-alkynylaryl carbamates was successfully accomplished through a strategy involving in situ carbamate alkaline hydrolysis under conventional heating or microwave irradiation, coupled with a subsequent heterocyclization step delivering the desired benzo[b]furans. A wide variety of new halobenzo[b]furans has been synthesized and their utility has been demonstrated by their further transformation. application/pdf http://hdl.handle.net/10259/10507 eng MDPI Transition Metal-Free Synthesis of Halobenzo[b]furans from O-Aryl Carbamates via o-Lithiation Reactions info:eu-repo/semantics/article TEXT RIUBU. Repositorio Institucional de la Universidad de Burgos Hispana