2026-05-14T10:08:41Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/106442026-05-13T09:03:01Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925

00925njm 22002777a 4500 dc Gómez Ayuso, Javier author Carreira Barral, Israel author Quesada Pato, Roberto author García Valverde, María author 2025-07 Herein we present a novel one-pot methodology for the synthesis of enantioenriched 2H-pyrrolespirosuccinimides by copper-catalyzed reactions on Ugi adducts derived from enantiopure α-alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen radical-shuttle (HRS) process explains the chemical and stereochemical results. This work demonstrates the efficient stereoselective synthesis of structurally unique, highly functionalized nitrogen heterocyclic systems using simple protocols and affordable starting materials. 1615-4150 https://hdl.handle.net/10259/10644 10.1002/adsc.202500166 1615-4169 Multicomponent reactions Radical reactions Copper catalys Succinimide Spirosuccinimide Spiro-2H-pyrrole Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions