2026-05-21T07:31:10Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/112872026-01-27T01:05:58Zcom_10259_4292com_10259_5086com_10259_2604com_10259_5827col_10259_4293col_10259_5828

Ortega Sanz, Irene 4fcf6553-8474-464b-8733-0e84571ee49b 600 Rovira Carballido, Jordi 490 600 0000-0001-6664-9484 Megías, Gregoria 6bd2bd5a-4cf8-4a2b-9967-810bbc1ecf44 600 Rivero Pérez, Maria Dolores 473 600 0000-0003-0907-4009 Melero Gil, Beatriz 356 600 0000-0001-8982-8186 2026-01-26T12:55:36Z 2026-01-26T12:55:36Z 2025-08 0882-4010 https://hdl.handle.net/10259/11287 10.1016/j.micpath.2025.107657 The ability of Campylobacter jejuni to survive and persist under harsh conditions is linked to the presence of flagella. This structure promotes the motility of the bacteria towards their optimum environment. The aim of this study was to examine the genetic basis for motility within 136 C. jejuni isolates through two different Genome-Wide Association Studies, gene presence/absence and Single Nucleotide Polymorphisms (SNPs). The motility phenotype was widely distributed across the phylogeny with large intra-lineage swarming performance variabilities. Accessory genes significantly associated with motility were found in four key genomic regions. One of these regions affected the Cj0727-Cj0733 operon, that encodes a putative ABC transporter system for phosphate uptake, while other influenced the capsule biosynthesis locus. Multiple SNPs mostly linked to increased motility were also discovered in clusters of genes, with special relevance to transport and membrane proteins. Therefore, the capsule and membrane composition might influence nutrient transfer, further impacting the protonmotive force that drives flagellar motor rotation in C. jejuni. The study provides novel genetic markers with a potential role in the motility phenotype of the pathogen. This work was supported by “La Caixa” Foundation and Caja Burgos Foundation [LCF/PR/PR18/51130007], and the Ministry of Education of the Government of Castilla y León [BU064P20]. Ortega-Sanz I received a predoctoral grant from the Junta de Castilla y León, cofinanced by the Ministry of Education of the Government of Castilla y León and the European Social Fund. application/pdf eng Elsevier Microbial Pathogenesis. 2025, V. 205, 107657 https://doi.org/10.1016/j.micpath.2025.107657 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Genomics Bacterial GWAS Phenotype Pangenome SNP Genetic marker Microbiología Genética Microbiology Genetics Genome-Wide association study to identify genetic markers associated with Campylobacter jejuni motility info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Microbial Pathogenesis 205 107657 THUMBNAIL Ortega-mp_2025.pdf.jpg Ortega-mp_2025.pdf.jpg IM Thumbnail image/jpeg 4931 https://riubu.ubu.es/bitstream/10259/11287/4/Ortega-mp_2025.pdf.jpg 6654ea4c21a25bd27838c4446ac9903c MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/11287/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 914 https://riubu.ubu.es/bitstream/10259/11287/2/license_rdf 24013099e9e6abb1575dc6ce0855efd5 MD5 2 ORIGINAL Ortega-mp_2025.pdf Ortega-mp_2025.pdf application/pdf 7344401 https://riubu.ubu.es/bitstream/10259/11287/1/Ortega-mp_2025.pdf 9c7abe69e8316fabcd6965b24d064a92 MD5 1 10259/11287 oai:riubu.ubu.es:10259/11287 2026-01-27 02:05:58.339 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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