2026-05-23T20:45:56Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/112952026-01-28T01:05:46Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863
Fernandez Becerra, Carmen
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500
Lelievre, Joel
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500
Ferrer, Mireia
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500
Antón Fidalgo, Nuria
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600
Thomson, Richard
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500
Peligero, Cristina
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500
Almela, Maria Jesus
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500
Lacerda, Marcus VG
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500
Herreros, Esperanza
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500
del Portillo, Hernando A
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500
2026-01-27T12:42:21Z
2026-01-27T12:42:21Z
2013-09
0074-0276
https://hdl.handle.net/10259/11295
10.1590/0074-0276108062013019
1678-8060
The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34+ hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites.
application/pdf
eng
Instituto Oswaldo Cruz, Ministério da Saúde
Memórias do Instituto Oswaldo Cruz. 2013, V. 108, n. 6, p. 801-803
https://doi.org/10.1590/0074-0276108062013019
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
CD34+ human haematopoietic stem cells
NIH 3T3 cells
Plasmodium
Hematología
Salud
Parasitología
Hematology
Health
Parasitology
Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Memórias do Instituto Oswaldo Cruz
108
6
801
803
THUMBNAIL
Fernandez-miwc_2013.pdf.jpg
Fernandez-miwc_2013.pdf.jpg
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LICENSE
license.txt
license.txt
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https://riubu.ubu.es/bitstream/10259/11295/3/license.txt
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ORIGINAL
Fernandez-miwc_2013.pdf
Fernandez-miwc_2013.pdf
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https://riubu.ubu.es/bitstream/10259/11295/1/Fernandez-miwc_2013.pdf
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10259/11295
oai:riubu.ubu.es:10259/11295
2026-01-28 02:05:46.93
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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