2026-04-18T11:52:59Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/113242026-02-05T01:05:52Zcom_10259_11322com_10259_3591com_10259.4_106com_10259_2604col_10259_11323
Repositorio Institucional de la Universidad de Burgos
author
Jones, Callum G.
author
Martínez Alonso, Marta
author
Gagg, Hannah
author
Kirby, Liam
author
Weinstein, Julia A.
author
Bryant, Helen E.
2026-02-04T13:07:00Z
2026-02-04T13:07:00Z
2024-09
0022-2623
https://hdl.handle.net/10259/11324
10.1021/acs.jmedchem.4c00869
1520-4804
Photodynamic therapy delivers more targeted cell killing than classical chemotherapy. It uses light-absorbing compounds, photosensitizers (PSs), to generate lethal reactive oxygen species (ROS) at sites of localized irradiation. Transition metal complexes are attractive PSs due to their photostability, visible-light absorption, and high ROS yields. Here, we introduce a low-molecular weight, photostable iridium complex, [Ir(thpy)2(benz)]Cl, 1, that localizes to the Golgi apparatus, mitochondria, and endoplasmic reticulum, absorbs visible light, phosphoresces strongly, generates 1O2 with 43% yield, and undergoes cellular elimination after 24 h. 1 shows low dark toxicity and under remarkably low doses (3 min, 20–30 mJ s–1 cm–2) of 405 or 455 nm light, it causes killing of bladder (EJ), malignant melanoma (A375), and oropharyngeal (OPSCC72) cancer cells, with high phototoxic indices > 100–378. 1 is also an efficient PS in 3D melanoma spheroids, with repeated short-time irradiation causing cumulative killing.
eng
Atribución 4.0 Internacional
Photostable Iridium(III) Cyclometallated Complex is an Efficient Photosensitizer for Killing Multiple Cancer Cell Lines and 3D Models under Low Doses of Visible Light
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/11324/1/Jones-jmc_2024.pdf
File
MD5
c491a04fcebaafd6f33eb34fc30d1a67
4223913
application/pdf
Jones-jmc_2024.pdf