2026-04-21T07:44:40Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/114352026-02-27T01:05:49Zcom_10259_4323com_10259_5086com_10259_2604col_10259_4330

Escobedo Monge, María Antonieta 20eb83ad-5b66-4ddb-867c-f559b00ebda7 600 Huerta Sainz, Sergio de la 845 600 0000-0002-6843-1419 Marcos Villa, Pedro A. 336 600 0000-0002-6890-8088 Esteban-Ollo, José Antonio 53fc1e56-814f-4259-8955-e7b58988df6e Montejo-Gil, Laura 2f73ce33-8275-45e7-a8fc-d98969991508 Conde-Rioll, María 6a8c0f52-11e6-44a0-8dbd-044e3ba7d372 Atilhan, Mert 51023856-6e72-4667-b27a-fe52e5115d61 600 Bol Arreba, Alfredo 70 600 0000-0003-4641-4826 Aparicio Martínez, Santiago 30 600 0000-0001-9996-2426 2026-02-26T07:22:49Z 2026-02-26T07:22:49Z 2025-06 1935-5130 https://hdl.handle.net/10259/11435 10.1007/s11947-025-03896-5 1935-5149 The extraction and purification of high-value phytosterol compounds from plant-derived feedstocks remains an important challenge in the fields of nutraceuticals, functional foods, and pharmaceutical applications. Conventional solvent-based extraction methods often rely on volatile, toxic, petroleum-derived solvents that raise sustainability concerns. Conventional solvent-based extraction methods often rely on volatile, toxic, petroleum-derived solvents such as n-hexane, ethanol, petroleum ether, or dichloromethane, which are considered volatile organic compounds (VOCs) and raise sustainability concerns. Natural Deep Eutectic Solvents (NADES) have emerged as alternative and promising green solvents for the selective recovery of phytosterols. In this work, we employ COSMO-RS (COnductor-like Screening MOdel for Real Solvents) modelling to systematically design and screen a large library of NADES formulations, with natural compounds as components, for the efficient extraction from vegetable sources of 19 typically occurring phytosterols. The COSMO-RS methodology allows the simulation of each NADES property, including their melting point and composition. It also calculates the activity coefficients with the phytosterols that will be used to rule out unsuitable combinations and evaluates toxicological parameters to assess their safety. After conducting nearly 2000 solubility tests, NADES demonstrated 1.5 to 5 times higher extractive capacity than common solvents for all phytosterols, with significantly lower volatilities. Finally, the use of NADES, especially the carvacrol-menthol mixture, significantly improves the extraction of phytosterols compared to conventional solvents, offering a more efficient, safe, and sustainable alternative, capable of dissolving a wide range of phytosterols. pen access funding provided by FEDER European Funds and the Junta de Castilla y León under the Research and Innovation Strategy for Smart Specialization (RIS3) of Castilla y León 2021-2027. This work was funded by the European Union (Horizon Program, Ref: HORIZON-CL4-2022-RESILIENCE-01-Convert2 green-GA 101092347) and the Junta de Castilla y León (Spain, Project NADESforNature, Ref.: BU047P23). application/pdf eng Springer Food and Bioprocess Technology. 2025, V. 18, n, 8, p. 7646–7660 https://doi.org/10.1007/s11947-025-03896-5 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Natural Deep Eutectic Solvents Phytosterol extraction COSMO-RS modelling Sustainable separation Plant-derived bioactives Fitoquímica Química ambiental Botanical chemistry Environmental chemistry Rational Design of Eco-Friendly Deep Eutectic Solvent Systems for the Recovery of High-Value Phytosterol Compounds info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Food and Bioprocess Technology 18 8 7646 7660 THUMBNAIL Escobedo-fbt_2025.pdf.jpg Escobedo-fbt_2025.pdf.jpg IM Thumbnail image/jpeg 4659 https://riubu.ubu.es/bitstream/10259/11435/4/Escobedo-fbt_2025.pdf.jpg df0ee22c8fe2cf5756a517b14e643685 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/11435/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/11435/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Escobedo-fbt_2025.pdf Escobedo-fbt_2025.pdf application/pdf 1405532 https://riubu.ubu.es/bitstream/10259/11435/1/Escobedo-fbt_2025.pdf 698f51fac4686a465daea8617670a4ae MD5 1 10259/11435 oai:riubu.ubu.es:10259/11435 2026-02-27 02:05:49.436 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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