2026-05-08T10:44:48Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/114622026-03-03T01:05:52Zcom_10259_9476com_10259.4_106com_10259_2604col_10259_9477

00925njm 22002777a 4500 dc Escobedo-Monge, Marlene Fabiola author Barrado, Enrique author Parodi-Román, Joaquín author Escobedo Monge, María Antonieta author Torres-Hinojal, María author Marugán Miguelsanz, José Manuel author 2021-10 Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population. 2072-6643 https://hdl.handle.net/10259/11462 10.3390/NU13103578 2072-6643 Hypocupremia Hypercupremia Inflammatory response Risk of zinc deficiency Serum zinc/copper ratio Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study