2026-05-28T13:38:25Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/116262026-05-15T06:14:40Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes Martínez González, Raúl Rubio Presa, Rubén Pedrosa Sáez, María de los Remedios Suárez Pantiga, Samuel Sanz Díez, Roberto Catalysis Molybdenum Nitroarenes N-polyheterocycles Tandem processes Química orgánica Chemistry, Organic The direct preparation of nitrogen-containing polyaromatic heterocycles in a single operational step from readily availablenitroarenes represents an attractive and sustainable alternative to traditional multistep approaches. In this context, this workdescribes an efficient and versatile methodology for the synthesis of fused N-polyheterocyclic scaffolds from functionalizednitroarenes and aldehydes catalyzed by dioxomolybdenum(VI) complexes and employing pinacol as a readily available andenvironmentally benign reductant. The protocol integrates nitro reduction, imine formation, and intramolecular cyclization ina single operational sequence. Careful fine-tuning of the reaction conditions proved crucial to minimizing competing pathways.This molybdenum-catalyzed strategy exhibits broad substrate scope, accommodating aromatic, aliphatic, and α,β-unsaturatedaldehydes, and enabling access to a variety of pharmaceutically relevant frameworks, such as pyrrolo[1,2-a]quinoxalines,indoloquinoxalines, γ-carbolines, imidazoquinolines, and phenanthridines. We gratefully acknowledge Ministerio de Ciencia, Innovación y Universidades (PID2023-148198NB-C21) and Junta de Castilla y León and FEDER (BU028P23) for financial support. Raúl Martínez-González thanks Junta de Castilla y León for a predoctoral contract. Samuel Suárez-Pantiga thanks a Ramón y Cajal (RYC2021-031533-I) contract funded by MICIN/AEI/10.13039/501100011033 and European Union “NextGenerationEU”/PRTR. Open access funding provided by FEDER European Funds and the Junta De Castilla y León under the Research and Innovation Strategy for Smart Specialization (RIS3) of Castilla y León 2021-2027 2026-05-14T11:21:46Z 2026-05-14T11:21:46Z 2026-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2193-5807 https://hdl.handle.net/10259/11626 10.1002/ajoc.70439 2193-5815 eng Asian Journal of Organic Chemistry. 2026, V. 15, n.5, e70439 https://doi.org/10.1002/ajoc.70439 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf Wiley https://riubu.ubu.es/bitstream/10259/11626/4/Mart%c3%adnez%e2%80%90ajoc_2026.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by-nc/4.0/ RIUBU. Repositorio Institucional de la Universidad de Burgos https://hdl.handle.net/10259/11626