2026-05-28T13:38:37Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/116262026-05-15T06:14:40Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

00925njm 22002777a 4500 dc Martínez González, Raúl author Rubio Presa, Rubén author Pedrosa Sáez, María de los Remedios author Suárez Pantiga, Samuel author Sanz Díez, Roberto author 2026-05 The direct preparation of nitrogen-containing polyaromatic heterocycles in a single operational step from readily availablenitroarenes represents an attractive and sustainable alternative to traditional multistep approaches. In this context, this workdescribes an efficient and versatile methodology for the synthesis of fused N-polyheterocyclic scaffolds from functionalizednitroarenes and aldehydes catalyzed by dioxomolybdenum(VI) complexes and employing pinacol as a readily available andenvironmentally benign reductant. The protocol integrates nitro reduction, imine formation, and intramolecular cyclization ina single operational sequence. Careful fine-tuning of the reaction conditions proved crucial to minimizing competing pathways.This molybdenum-catalyzed strategy exhibits broad substrate scope, accommodating aromatic, aliphatic, and α,β-unsaturatedaldehydes, and enabling access to a variety of pharmaceutically relevant frameworks, such as pyrrolo[1,2-a]quinoxalines,indoloquinoxalines, γ-carbolines, imidazoquinolines, and phenanthridines. 2193-5807 https://hdl.handle.net/10259/11626 10.1002/ajoc.70439 2193-5815 Catalysis Molybdenum Nitroarenes N-polyheterocycles Tandem processes Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes