2026-05-28T13:38:16Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/116262026-05-15T06:14:40Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

Martínez González, Raúl 9461e435-c843-4e62-8955-343425bde4a0 Rubio Presa, Rubén 493 600 0000-0002-9938-2058 Pedrosa Sáez, María de los Remedios 422 600 0000-0001-7083-8093 Suárez Pantiga, Samuel 544 600 0000-0002-4249-7807 Sanz Díez, Roberto 531 600 0000-0003-2830-0892 2026-05-14T11:21:46Z 2026-05-14T11:21:46Z 2026-05 2193-5807 https://hdl.handle.net/10259/11626 10.1002/ajoc.70439 2193-5815 The direct preparation of nitrogen-containing polyaromatic heterocycles in a single operational step from readily availablenitroarenes represents an attractive and sustainable alternative to traditional multistep approaches. In this context, this workdescribes an efficient and versatile methodology for the synthesis of fused N-polyheterocyclic scaffolds from functionalizednitroarenes and aldehydes catalyzed by dioxomolybdenum(VI) complexes and employing pinacol as a readily available andenvironmentally benign reductant. The protocol integrates nitro reduction, imine formation, and intramolecular cyclization ina single operational sequence. Careful fine-tuning of the reaction conditions proved crucial to minimizing competing pathways.This molybdenum-catalyzed strategy exhibits broad substrate scope, accommodating aromatic, aliphatic, and α,β-unsaturatedaldehydes, and enabling access to a variety of pharmaceutically relevant frameworks, such as pyrrolo[1,2-a]quinoxalines,indoloquinoxalines, γ-carbolines, imidazoquinolines, and phenanthridines. We gratefully acknowledge Ministerio de Ciencia, Innovación y Universidades (PID2023-148198NB-C21) and Junta de Castilla y León and FEDER (BU028P23) for financial support. Raúl Martínez-González thanks Junta de Castilla y León for a predoctoral contract. Samuel Suárez-Pantiga thanks a Ramón y Cajal (RYC2021-031533-I) contract funded by MICIN/AEI/10.13039/501100011033 and European Union “NextGenerationEU”/PRTR. Open access funding provided by FEDER European Funds and the Junta De Castilla y León under the Research and Innovation Strategy for Smart Specialization (RIS3) of Castilla y León 2021-2027 application/pdf eng Wiley Asian Journal of Organic Chemistry. 2026, V. 15, n.5, e70439 https://doi.org/10.1002/ajoc.70439 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Catalysis Molybdenum Nitroarenes N-polyheterocycles Tandem processes Química orgánica Chemistry, Organic Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Asian Journal of Organic Chemistry 15 5 https://ror.org/051jb1k20 Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE) hybrid-oa 1 2493,54 EUR 9100224283 John Wiley & Sons 2026-04-24 2025-01-01 2028-12-31 10.1002/ajoc.70439 THUMBNAIL Martínez‐ajoc_2026.pdf.jpg Martínez‐ajoc_2026.pdf.jpg IM Thumbnail image/jpeg 4866 https://riubu.ubu.es/bitstream/10259/11626/4/Mart%c3%adnez%e2%80%90ajoc_2026.pdf.jpg cfd9547315d70c271acdfd58f0f2e7a6 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/11626/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 914 https://riubu.ubu.es/bitstream/10259/11626/2/license_rdf 24013099e9e6abb1575dc6ce0855efd5 MD5 2 ORIGINAL Martínez‐ajoc_2026.pdf Martínez‐ajoc_2026.pdf application/pdf 1586024 https://riubu.ubu.es/bitstream/10259/11626/1/Mart%c3%adnez%e2%80%90ajoc_2026.pdf 928d8dff37c12fcb9bb1873eb4e4272c MD5 1 10259/11626 oai:riubu.ubu.es:10259/11626 2026-05-15 08:14:40.944 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es RWwgYXV0b3IgY29tbyDDum5pY28gdGl0dWxhciBkZSBsb3MgZGVyZWNob3MgZGUgcHJvcGllZGFkIGludGVsZWN0dWFsIGRlIGxhIG9icmEsIG8gZGlzcG9uaWVuZG8gZGUgbG9zIGRlYmlkb3MgcGVybWlzb3MgZGUgbG9zIG90cm9zIHRpdHVsYXJlcywgc2kgbG9zIGh1YmllcmEsIHkgZW4gdmlydHVkIGRlIGxvcyBkZXJlY2hvcyBxdWUgbGUgY29uZmllcmUgbGEgbGVnaXNsYWNpw7NuIHZpZ2VudGUgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIHkgZGVyZWNob3MgZGUgYXV0b3IsIA0KQVVUT1JJWkEgYSBsYSBVbml2ZXJzaWRhZCBkZSBCdXJnb3MgYSBkaWZ1bmRpciwgZGUgbWFuZXJhIGdyYXR1aXRhLCBlbCBjb250ZW5pZG8gZGUgbG9zIGFyY2hpdm9zIGRpZ2l0YWxlcyBxdWUgY29ycmVzcG9uZGVuIGFsIGRvY3VtZW50byBkZXNjcml0byBhbnRlcmlvcm1lbnRlLCBjb24gY2Fyw6FjdGVyIG5vIGV4Y2x1c2l2byB5IGRlIG1hbmVyYSBww7pibGljYSBlbiBhY2Nlc28gYWJpZXJ0byBhIHRyYXbDqXMgZGUgSW50ZXJuZXQsIHBhcmEgbG8gcXVlIGxhIEJpYmxpb3RlY2EgcHJvY2VkZXLDoSBhIGFyY2hpdmFybG9zIGVuIGVsIFJlcG9zaXRvcmlvIEluc3RpdHVjaW9uYWwuIEFzaW1pc21vIGF1dG9yaXphIGEgbGEgVW5pdmVyc2lkYWQgZGUgQnVyZ29zIGEgcmVhbGl6YXIgbGFzIHRyYW5zZm9ybWFjaW9uZXMgbmVjZXNhcmlhcyBkZSBmb3JtYXRvLCBubyBkZSBjb250ZW5pZG8sIHBhcmEgZ2FyYW50aXphciBsYSBwcmVzZXJ2YWNpw7NuIHkgZWwgYWNjZXNvIGVuIGVsIGZ1dHVyby4NCg0KRWwgYXV0b3IgZGlzcG9uZSwgZW4gdG9kbyBjYXNvLCBkZWwgZGVyZWNobyBhIHJldm9jYXIgZXN0YSBhdXRvcml6YWNpw7NuLg0KDQpMYSBjZXNpw7NuIGRlIGRlcmVjaG9zIGRlIGVzdGEgb2JyYSBzZSBlbmN1ZW50cmEgc3VqZXRhIGEgbGEgbGVnaXNsYWNpw7NuIHZpZ2VudGUgc29icmUgcHJvcGllZGFkIGludGVsZWN0dWFsIHkgZGVyZWNob3MgZGUgYXV0b3Iu