2026-04-17T20:10:51Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/42572021-11-10T09:38:26Zcom_10259_4249com_10259_5086com_10259_2604col_10259_4250
Repositorio Institucional de la Universidad de Burgos
author
Herrero Gutiérrez, Ana
author
Reguera Alonso, Celia
author
Ortiz Fernández, Mª Cruz
author
Sarabia Peinador, Luis Antonio
2016-10-19T11:28:07Z
2016-10-19T11:28:07Z
2014-04
0169-7439
http://hdl.handle.net/10259/4257
10.1016/j.chemolab.2013.12.001
The optimization of a GC–MS analytical procedure which includes derivatization, Quick Easy Cheap Effective Rugged and Safe (QuEChERS) and programmed temperature vaporization (PTV) using design of experiments is performed to determine 2,6-dichlorobenzonitrile (dichlobenil) and 2,6-dichlorobenzamide (BAM) in onions, using 3,5-dichlorobenzonitrile and 2,4-dichlorobenzamide as internal standards. The use of a central composite design and two D-optimal designs, together with the desirability function, makes it possible to significantly reduce the economic, time and environmental cost of the study. The usefulness of PARAFAC2 for solving problems as the interference of unexpected derivatization artifacts unavoidably linked to some derivatization agents, or the presence of coeluents from the complex matrix, which share m/z ratios with the target compounds, is shown. The limits of decision (CCα) of the optimized procedure, 5.00 μg kg− 1 for dichlobenil and 1.55 μg kg− 1 for BAM (α = 0.05), are below the maximum residue limit (MRL) established by the EU for dichlobenil (20 μg kg− 1) in this commodity.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
PTV–GC–MS
D-optimal design
Parallel factor analysis
Desirability function
Dichlobenil
SANCO/12495/2001
Determination of dichlobenil and its major metabolite (BAM) in onions by PTV–GC–MS using PARAFAC2 and experimental design methodology
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/4257/1/Herrero-CILS_2014.pdf
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URL
https://riubu.ubu.es/bitstream/10259/4257/6/Herrero-CILS_2014.pdf.txt
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Herrero-CILS_2014.pdf.txt