2026-06-29T21:08:03Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/42812022-04-29T12:02:48Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

Feberero, Claudia Velasco, Rocío Sanz Díez, Roberto 2016-11-24T08:10:48Z 2017-11-01T03:45:07Z 2016-11 1434-193X http://hdl.handle.net/10259/4281 New dihalosalicylamides and trihalophenol derivatives have been synthesized from easily available O-(3,n-dihalophenyl) N,N-diethylcarbamates by using a directed ortho-metalation (DoM) strategy. The o-lithiation reactions with sBuLi take place regioselectively at the doubly activated C-2 position, which demonstrates the ability of O-carbamates as directed metalating groups. In addition, highly functionalized arylnitriles were accessed from organolithium intermediates by using a tandem transnitrilation/SNAr reaction sequence. Junta de Castilla y León (Consejería de Educación) and FEDER (BU237U13 and BU076U16) as well as the Ministerio de Economía y Competitividad (MINECO) and FEDER (CTQ2013-48937-C2-1-P) application/pdf spa Wiley-VCH Verlag European Journal of Organic Chemistry. 2016, n. 33, p. 5445–5587 http://dx.doi.org/10.1002/ejoc.201600933 Chemistry, Organic Química orgánica ortho-Lithiation Reactions of O-(3,n-Dihalophenyl) N,N-Diethylcarbamates: Synthesis of Dihalosalicylamides and 2,3,n-Trihalophenol Derivatives info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/openAccess