2026-04-28T07:49:54Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/42822022-12-20T11:21:21Zcom_10259_3593com_10259_5086com_10259_2604com_10259_4365com_10259_4883com_10259_3596col_10259_3594col_10259_4366col_10259_4884col_10259_3597

Gil García, Rubén 232 500 Ugalde, María 559 600 Busto Vázquez, Natalia 83 500 0000-0001-9637-1209 Lozano Ordóñez, Héctor J. 771663b0-aa21-409d-90e5-48e734c216f5 500 Leal Villalba, José María 314 500 0000-0001-9676-108X Pérez, Begoña 446 600 Madariaga, Gotzon 0f2d197b-c4d0-47fd-9235-e4db4aaa9651 600 Insausti, Maite 76f80144-958c-4b7f-b6e3-e88cf5e2a404 500 Lezama, Luis 9b1ac1a2-e0b6-4d1f-afe9-c7c94f068da9 600 Sanz Díez, Roberto 531 500 0000-0003-2830-0892 Gómez Sainz, Lidia M. 243 600 García Ruiz, Begoña 217 500 0000-0002-0817-1651 García Tojal, Javier 221 500 0000-0003-3816-0483 2016-11-24T08:30:17Z 2017-12-07T03:45:06Z 2016-12 1477-9226 http://hdl.handle.net/10259/4282 Thiosemicarbazones and their metal derivatives have long been screened as antitumor agents, and their interactions with DNA have been analysed. Herein, we describe the synthesis and characterization of compounds containing [CuL]+ entities (HL = pyridine-2-carbaldehyde thiosemicarbazone) and adenine, cytosine or 9-methylguanine, and some of their corresponding nucleotides. For the first time, crystal structures of adenine- and 9-methylguanine-containing thiosemicarbazone complexes are reported. To the best of our knowledge, the first study on the affinity thiosemicarbazone–RNA is also provided here. Experimental and computational studies have shown that [CuL(OH2)]+ entities at low concentration intercalate into dsRNA poly(rA)·poly(rU) through strong hydrogen bonds involving uracil residues and π–π stacking interactions. In fact, noncovalent interactions are present both in the solid state and in solution. This behaviour diverges from that observed with DNA duplexes and creates an optimistic outlook in achieving selective binding to RNA for subsequent possible medical applications. Obra Social “la Caixa” (OSLC-2012-007), Ministerio de Economía y Competitividad and FEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371- REDT, MAT2012-34740 and CTQ2014-58812-C2-2-R), Junta de Castilla y León (BU237U13), the Basque Government (IT-779- 13), Gerencia Regional de Salud, Consejería de Sanidad, Junta de Castilla y León (GRS 1023/A/14 and GR172). application/pdf eng Royal Society of Chemistry Dalton transactions, 2016, n. 45, p. 45, 18704-18718 http://dx.doi.org/10.1039/C6DT02907H Chemistry, Organic Química orgánica Selectivity of a thiosemicarbazonatocopper(II) complex towards duplex RNA. Relevant noncovalent interactions both in solid state and solution info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/openAccess THUMBNAIL Gil-DT_2016.pdf.jpg Gil-DT_2016.pdf.jpg IM Thumbnail image/jpeg 5352 https://riubu.ubu.es/bitstream/10259/4282/4/Gil-DT_2016.pdf.jpg bfc810ddff3b9649046984548e0e610c MD5 4 ORIGINAL Gil-DT_2016.pdf Gil-DT_2016.pdf application/pdf 1568241 https://riubu.ubu.es/bitstream/10259/4282/1/Gil-DT_2016.pdf 5212ccc59350e337e1cb62a6bb935f83 MD5 1 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/4282/2/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 2 TEXT Gil-DT_2016.pdf.txt Gil-DT_2016.pdf.txt Extracted text text/plain 85438 https://riubu.ubu.es/bitstream/10259/4282/3/Gil-DT_2016.pdf.txt a2848ebff0b4f72b5451b966d83e5095 MD5 3 10259/4282 oai:riubu.ubu.es:10259/4282 2022-12-20 12:21:21.392 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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