2026-04-28T11:37:54Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/47432022-04-29T12:02:46Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925

Knight, Nicola J. . 2366cbd0-fca0-47d5-a5e1-c8febb32c20e 500 Hernando Santa Cruz, Elsa 279 500 Haynes, Cally J. E. . 8e776f5e-eec0-4904-bdda-10775e92410d 500 Busschaert, Nathalie 02de573e-58a6-4003-b355-455c7aacb0ed 500 Clarke, Harriet J. . 3138c755-020f-4e8d-a821-1eb4ee76c111 500 Takimoto, Koji 22ff830f-0730-4f8e-b52b-08a593f2f661 500 García Valverde, María 222 500 Frey, Jeremy G. . 5276a0f3-bbb4-4495-9d1b-bae788b00472 500 Quesada Pato, Roberto 458 500 Gale, Philip A. . 87a9ac01-c865-4edf-8093-2da2d3072bf1 500 2018-03-07T10:33:46Z 2018-03-07T10:33:46Z 2016-02 2041-6520 http://hdl.handle.net/10259/4743 10.1039/c5sc03932k The transmembrane anion transport activity of 43 synthetic molecules based on the structure of marine alkaloid tambjamine were assessed in model phospholipid (POPC) liposomes. The anionophoric activity of these molecules showed a parabolic dependence with lipophilicity, with an optimum range for transport efficiency. Using a quantitative structure–transport activity (QSAR) approach it was possible to rationalize these results and to quantify the contribution of lipophilicity to the transport activity of these derivatives. While the optimal value of log P and the curvature of the parabolic dependence is a property of the membrane (and so similar for the different series of substituents) we found that for relatively simple substituents in certain locations on the tambjamine core, hydrophobic interactions clearly dominate, but for others, more specific interactions are present that change the position of the membrane hydrophobicity parabolic envelope. RQ acknowledges funding from Consejer´ıa de Educaci´on de la Junta de Castilla y Le´on (Project BU340U13) and Fundaci´o la Marat´o de TV3 (20132730). PAG thanks the EPSRC for funding (EP/J009687/1 and EP/K039466/1). COST CM1005 Supramolecular Chemistry in Water for a STSM (EH). JGF thanks the EPSRC (GR/R67729 & EP/ K003569) for funding application/pdf eng Royal Society of Chemistry Chemical Science. 2016, V. 7, n. 2, p. 1600-1608 https://doi.org/10.1039/c5sc03932k info:eu-repo/grantAgreement/JCyL/BU340U13 info:eu-repo/grantAgreement/Fundació la Marató de TV3/20132730 info:eu-repo/grantAgreement/EPSRC/EP-J009687-1 info:eu-repo/grantAgreement/EPSRC/EP-K039466-1 info:eu-repo/grantAgreement/EPSRC/GR-R67729 info:eu-repo/grantAgreement/EPSRC/EP- K003569 Attribution 3.0 Unported http://creativecommons.org/licenses/by/3.0/ info:eu-repo/semantics/openAccess Chemistry, Organic Química orgánica QSAR analysis of substituent effects on tambjamine anion transporters info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/4743/8/license_rdf f9a6a4096bf314846151c97900b2090d MD5 8 THUMBNAIL Knight-CS_2016.pdf.jpg Knight-CS_2016.pdf.jpg IM Thumbnail image/jpeg 4963 https://riubu.ubu.es/bitstream/10259/4743/7/Knight-CS_2016.pdf.jpg 71bb56640942dcc51a3635d033447766 MD5 7 ORIGINAL Knight-CS_2016.pdf Knight-CS_2016.pdf application/pdf 780479 https://riubu.ubu.es/bitstream/10259/4743/1/Knight-CS_2016.pdf 6e0193fd8feb6de524b472c6e629a5b9 MD5 1 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/4743/5/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 5 TEXT Knight-CS_2016.pdf.txt Knight-CS_2016.pdf.txt Extracted text text/plain 38331 https://riubu.ubu.es/bitstream/10259/4743/6/Knight-CS_2016.pdf.txt d5e8b1c2332c6bca71cc751d450b4f58 MD5 6 10259/4743 oai:riubu.ubu.es:10259/4743 2022-04-29 14:02:46.334 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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