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oai:riubu.ubu.es:10259/47472022-04-29T12:02:48Zcom_10259_4249com_10259_5086com_10259_2604col_10259_4250

Benito, José M. . 71529d8f-2d70-46eb-901c-688a601dace2 500 Ortiz Fernández, Mª Cruz 406 500 León, Agathe . cd7251dd-c7ce-4cf5-a157-264e167f25e5 500 Sarabia Peinador, Luis Antonio 534 500 Ligos, José M. . a941013d-e8a9-47ca-8d2f-2d81282e9204 500 Montoya, María . 9e761b17-1aac-427b-8745-f1b691212595 500 García, Marcial . fcb460d2-7a81-4030-9569-54f922bb80f2 500 Ruiz Mateos, Ezequiel . 7c8c1610-cd93-4e2a-9fe8-0e989ea232d0 500 Palacios, Rosario . fd7f7bf0-d1f5-4b16-9b5a-21fb559e404d 500 Cabello, Alfonso . 2b5b813b-4aba-4298-9639-9e888a865a71 500 Restrepo, Clara . ebe0cd79-07d6-444c-a1a1-03af7b62409c 500 Rodríguez, Carmen . 1a5878cd-4664-4bf1-b314-cb17fd6fffe5 500 Romero, Jorge del . b7a59741-90aa-41d7-aa08-1c352e904fa2 500 Leal, Manuel . 5dfa068b-d9d6-43fd-b6b1-1d18b5ffddab 500 Muñoz Fernández, María A. . b52cc098-2953-4324-a626-1c81ae1ae0a5 500 Alcamí, José . 7feee339-d666-4be6-bcc6-60ef9c9eef74 500 García, Felipe . e6aadb8e-d344-45ac-9b51-c969f527b1b0 500 Górgolas, Miguel . d955066e-de20-4cdb-ba7f-21d02b27c555 500 Rallón, Norma . 3c3a61dd-fcb0-407a-ba9e-76a6d20446a2 500 2018-03-08T11:06:50Z 2018-03-08T11:06:50Z 2018-02 1741-7015 http://hdl.handle.net/10259/4747 10.1186/s12916-018-1026-6 Despite long-lasting HIV replication control, a significant proportion of elite controller (EC) patients may experience CD4 T-cell loss. Discovering perturbations in immunological parameters could help our understanding of the mechanisms that may be operating in those patients experiencing loss of immunological control. Methods A case–control study was performed to evaluate if alterations in different T-cell homeostatic parameters can predict CD4 T-cell loss in ECs by comparing data from EC patients showing significant CD4 decline (cases) and EC patients showing stable CD4 counts (controls). The partial least-squares–class modeling (PLS-CM) statistical methodology was employed to discriminate between the two groups of patients, and as a predictive model. Results Herein, we show that among T-cell homeostatic alterations, lower levels of naïve and recent thymic emigrant subsets of CD8 cells and higher levels of effector and senescent subsets of CD8 cells as well as higher levels of exhaustion of CD4 cells, measured prior to CD4 T-cell loss, predict the loss of immunological control. Conclusions These data indicate that the parameters of T-cell homeostasis may identify those EC patients with a higher proclivity to CD4 T-cell loss. Our results may open new avenues for understanding the mechanisms underlying immunological progression despite HIV replication control, and eventually, for finding a functional cure through immune-based clinical trials. projects RD12/0017/0031, RD16/0025/ 0013, and SAF2015-66193-R as part of the Health Research and Development Strategy, State Plan for Scientific and Technical Research and Innovation (2008– 2011 and 2013–2016) and cofinanced by the Institute of Health Carlos III (ISCIII), Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund. NR is a Miguel Servet investigator from the ISCIII (CP14/00198), Madrid, Spain. C Restrepo was funded by project RD12/0017/ 0031 and is currently funded by project RD16/0025/0013. M García is a predoctoral student co-funded by grant CP14/00198 and an Intramural Research Scholarship from Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD). application/pdf eng BioMed Central BMC Medicine. 2018 https://doi.org/10.1186/s12916-018-1026-6 info:eu-repo/grantAgreement/ISCIII/RD12/0017/0031 info:eu-repo/grantAgreement/ISCIII/RD16/0025/0013 info:eu-repo/grantAgreement/SAF2015-66193-R Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Elite controllers CD4 T-cell loss Class modeling T-cell homeostatic parameters CD8 exhaustion Chemistry Mathematics Química Matemáticas Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/4747/8/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 8 THUMBNAIL Benito-BMCM_2018.pdf.jpg Benito-BMCM_2018.pdf.jpg IM Thumbnail image/jpeg 4863 https://riubu.ubu.es/bitstream/10259/4747/7/Benito-BMCM_2018.pdf.jpg f83326241484b637a3f5a5baaf3070ed MD5 7 ORIGINAL Benito-BMCM_2018.pdf Benito-BMCM_2018.pdf application/pdf 1953537 https://riubu.ubu.es/bitstream/10259/4747/1/Benito-BMCM_2018.pdf 28fd55b5b36b1a22f88ab9ee278796b3 MD5 1 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/4747/5/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 5 TEXT Benito-BMCM_2018.pdf.txt Benito-BMCM_2018.pdf.txt Extracted text text/plain 55106 https://riubu.ubu.es/bitstream/10259/4747/6/Benito-BMCM_2018.pdf.txt 266035ea003cf66968aaef06335a3382 MD5 6 10259/4747 oai:riubu.ubu.es:10259/4747 2022-04-29 14:02:48.663 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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