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oai:riubu.ubu.es:10259/48762021-11-10T09:38:19Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925

Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs Hernando Santa Cruz, Elsa Soto Cerrato, Vanessa Cortés Arroyo, Susana . Pérez Tomás, Ricardo Quesada Pato, Roberto Química orgánica Chemistry, Organic Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, have been synthesized. These compounds proved to be highly efficient transmembrane anion transporters in model liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or the alkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity of these compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50 values in the low micromolar range as well as modify the intracellular pH, inducing the basification of acidic organelles. Consejería de Educación de la Junta de Castilla y León (Project BU340U13) and Fundació la Maratón de TV3. 2018-08-23T08:29:20Z 2018-08-23T08:29:20Z 2014-03 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 1477-0520 http://hdl.handle.net/10259/4876 10.1039/c3ob42341g eng Organic & Biomolecular Chemistry. 2014, V. 12, n. 11, p. 1771-1778 https://doi.org/10.1039/c3ob42341g info:eu-repo/grantAgreement/JCyL/BU340U13 info:eu-repo/grantAgreement/TV3Foundation/20132732 info:eu-repo/semantics/openAccess application/pdf Royal Society of Chemistry