2026-06-30T03:25:03Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/49242021-11-10T09:38:25Zcom_10259_3593com_10259_5086com_10259_2604com_10259_3596col_10259_3594col_10259_3597

Rubio Presa, Rubén Pedrosa Sáez, María de los Remedios Fernández Rodríguez, Manuel A. Arnáiz García, Francisco Javier Sanz Díez, Roberto 2018-09-07T10:20:10Z 2018-10-06T02:45:06Z 2017-10 1523-7060 http://hdl.handle.net/10259/4924 10.1021/acs.orglett.7b02792 A novel domino reduction/imine formation/intramolecular cyclization/oxidation for the efficient synthesis of pyrrolo(indolo)[1,2-a]quinoxalines and pyrrolo(indolo)[3,2-c]-quinolines from readily available nitrobenzenes and glycols is reported. The process utilizes the carbonyl byproduct of the initial dioxomolybdenum(VI)-catalyzed reduction of nitroaromatics with glycols as a reagent for the imine generation. This method represents the first sustainable domino reaction for the preparation of biologically relevant heterocycles that internally incorporates the waste formed in the first step to the final product. eng info:eu-repo/semantics/openAccess Molybdenum-Catalyzed Synthesis of Nitrogenated Polyheterocycles from Nitroarenes and Glycols with Reuse of Waste Reduction By-product info:eu-repo/semantics/article