2026-05-12T02:17:45Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/49292022-12-19T12:26:22Zcom_10259_3593com_10259_5086com_10259_2604com_10259_3596col_10259_3594col_10259_3597

García Tojal, Javier 221 500 0000-0003-3816-0483 Gil García, Rubén 6703bbf8-80d1-4d05-a037-a6ffd2f19600 500 Fouz Cuesta, Víctor Ivo 178 600 Madariaga, Gotzon 0f2d197b-c4d0-47fd-9235-e4db4aaa9651 500 Lezama, Luis 9b1ac1a2-e0b6-4d1f-afe9-c7c94f068da9 500 Galletero, María S. dc3376b6-9c58-4914-98ba-7ded89492e2d 500 Borrás, Joaquín e76bcd74-c3d7-4997-82a7-59f3c9a26017 500 Nollmann, Friederike I. 225e67c6-0a1a-471e-8119-2206b8824cf4 500 García Girón, Carlos a191a584-8644-4b54-b047-affd824c0493 500 Alcaraz, Raquel f37b3220-2c62-4524-ab2c-60d6a8de878a 500 Cavia Saiz, Mónica 116 500 0000-0001-5132-381X Muñiz Rodríguez, Pilar 380 500 0000-0002-9306-0082 Palacios, Óscar 09f1f1aa-f24e-4d4c-889c-b2db8c13dee7 600 Samper, Katia G. a5503711-3831-4506-8666-df7d13758a9e 500 Rojo, Teófilo fc84cd25-6072-4bc8-a0d1-a1c2dd4699f8 500 2018-09-10T08:48:17Z 2018-03 2020-04 0162-0134 http://hdl.handle.net/10259/4929 10.1016/j.jinorgbio.2017.12.005 Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands. Obra Social “la Caixa” (OSLC-2012-007), Ministerio de Economía y Competitividad and FEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371-REDT, MAT2015-66441-P, BIO2015-67358-C2-2-P), Junta de Castilla y León (BU237U13), Gerencia Regional de Salud, Consejería de Sanidad, Junta de Castilla y León (GRS 1023/A/14), the Basque Government (project IT-779-13) application/pdf eng Elsevier Journal of Inorganic Biochemistry. 2018, V. 180, p. 69–79 https://doi.org/10.1016/j.jinorgbio.2017.12.005 info:eu-repo/grantAgreement/FundaciónLaCaixa/ OSLC-2012-007 info:eu-repo/grantAgreement/MINECO/CTQ2013-48937-C2-1-P info:eu-repo/grantAgreement/MINECO/CTQ2015-70371-REDT info:eu-repo/grantAgreement/MINECO/MAT2015-66441-P info:eu-repo/grantAgreement/MINECO/BIO2015-67358-C2-2-P info:eu-repo/grantAgreement/JCyL/BU237U13 info:eu-repo/grantAgreement/JCyL/GRS 1023/A/14 info:eu-repo/grantAgreement/GV/IT-779-13 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Colon carcinoma Copper Molecular magnetism Thiosemicarbazone Química inorgánica Aparato digestivo-Enfermedades Chemistry, Inorganic Digestive organs-Diseases Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/4929/8/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 8 THUMBNAIL Garcia-jib_2018.pdf.jpg Garcia-jib_2018.pdf.jpg IM Thumbnail image/jpeg 4075 https://riubu.ubu.es/bitstream/10259/4929/7/Garcia-jib_2018.pdf.jpg bfcc714153acd91879a8263f4c71d09b MD5 7 ORIGINAL Garcia-jib_2018.pdf Garcia-jib_2018.pdf application/pdf 741210 https://riubu.ubu.es/bitstream/10259/4929/1/Garcia-jib_2018.pdf dbe626ad0d0500a8637e4107d85a98c5 MD5 1 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/4929/5/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 5 TEXT Garcia-jib_2018.pdf.txt Garcia-jib_2018.pdf.txt Extracted text text/plain 59116 https://riubu.ubu.es/bitstream/10259/4929/6/Garcia-jib_2018.pdf.txt fb14ae039487be9d3dcc3b37aa8456b0 MD5 6 10259/4929 oai:riubu.ubu.es:10259/4929 2022-12-19 13:26:22.196 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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