2026-04-29T19:49:28Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/49742021-11-10T09:38:25Zcom_10259_4725com_10259_5086com_10259_2604col_10259_4726
Mateos, Rosa María .
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500
Jiménez, Gema .
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500
Álvarez Gil, Carmen .
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500
Visiedo, Francisco .
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500
Rivera Rodríguez, Fátima .
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500
Santos Rosendo, Celeste .
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500
Rodríguez Pareja, Antonia .
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500
Perdomo Hernández, Germán M.
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500
Lechuga Sancho, Alfonso .
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2018-10-22T11:35:32Z
2018-10-22T11:35:32Z
2018
2314-6133
http://hdl.handle.net/10259/4974
10.1155/2018/5106174
Low birth weight increases neonatal morbidity and mortality, and surviving infants have increased risk of metabolic and
cardiovascular disturbances later in life, as well as other neurological, psychiatric, and immune complications. A gestational
excess of glucocorticoids (GCs) is a well-known cause for fetal growth retardation, but the biological basis for this association
remains elusive. Placental growth is closely related to fetal growth. The placenta is the main regulator of nutrient transport to
the fetus, resulting from the difference between placental nutrient uptake and the placenta’s own metabolism. The aim of this
study was to analyze how excess hydrocortisone affects placental glucose and lipid metabolism. Human placenta explants from
term physiological pregnancies were cultured for 18 hours under different hydrocortisone concentrations (2.75, 5.5, and 55mM;
1, 2, and 20mg/ml). Placental glucose and lipid uptake and the metabolic partitioning of fatty acids were quantified by isotopic
techniques, and expression of specific glucose transporterGLUT1was quantified bywestern blot.Cell viabilitywas assessed byMTT,
immunohistochemistry and caspase activity. We found that excess hydrocortisone impairs glucose uptake and lipoprotein lipase
(LPL) activity, coincident with a GC-dose dependent inhibition of fatty acid oxidation and esterification. None of the experimental
conditions showed an increased cell death. In conclusion, our results show that GC overexposure exerts a dysfunctional effect on
lipid transport and metabolism and glucose uptake in human placental explants. These findings could well be directly related to
a reduced placental growth and possibly to a reduced supply of nutrients to the fetus and the consequent fetal growth retardation
and metabolic programming.
application/pdf
eng
Hindawi Publishing Corporation
BioMed research international. 2018, V. 2018, Article ID 5106174, 11 pages
https://doi.org/10.1155/2018/5106174
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Endocrinología
Obstetricia
Endocrinology
Obstetrics
Excess hydrocortisone hampers placental nutrient uptake disrupting cellular metabolism
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
CC-LICENSE
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Mateos-bri_2018.pdf
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Mateos-bri_2018.pdf.txt
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10259/4974
oai:riubu.ubu.es:10259/4974
2021-11-10 10:38:25.996
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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