2026-04-29T03:14:07Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/49952021-11-10T09:38:26Zcom_10259_4725com_10259_5086com_10259_2604col_10259_4726

Bartha, Jose L. . 78b8ad54-afe6-4683-9695-6981c64cfb7f 500 Bugatto, Fernando . 386b1eed-ba66-4309-ac07-2b2290487df4 500 Fernández Deudero, Álvaro . 0a7e76fc-6c7e-4873-b9d0-bf867878df4f 500 Fernández Macías, Rosa . 24b329cd-0a1b-47b3-ada5-a9bd62728862 500 Perdomo Hernández, Germán M. 433 500 2018-11-05T09:36:02Z 2018-11-05T09:36:02Z 2016-11 1476-511X http://hdl.handle.net/10259/4995 10.1186/s12944-016-0373-6 Background: Abnormal fatty acid oxidation (FAO) is associated with maternal and fetal complications during pregnancy. The contribution of maternal and fetal tissues to FAO capacity during late pregnancy is important to understand the pathophysiology of pregnancy-associated complications. The aim of this study was to determine the expression levels of mitochondrial FAO enzymes in maternal and fetal tissues during late normal pregnancy. Methods: We have measured by Real-time PCR the levels of long- and medium -chain acyl-CoA dehydrogenase (LCHAD and MCAD), two acyl-CoA dehydrogenases that catalyze the initial step in the mitochondrial FAO spiral. Results: LCHAD and MCAD were expressed in maternal skeletal muscle, subcutaneous adipose tissue, placenta, and maternal and fetal blood cells. LCHAD gene expression was four- to 16-fold higher than MCAD gene expression in placenta, adipose tissue and skeletal muscle. In contrast, MCAD gene expression was ~5-fold higher in fetal blood than maternal blood (p = 0.02), whereas LCHAD gene expression was similar between fetal blood and maternal blood (p =0.91). Conclusions: LCHAD and MCAD are differentially expressed in maternal and fetal tissues during normal late pregnancy, which may represent a metabolic adaptation in response to physiological maternal dyslipidemia during late pregnancy. Consejeria de Salud, Junta de Andalucía Num Expte: 0269/05. application/pdf eng BioMed Central Lipids in Health and Disease. 2016. V. 15, 200 https://doi.org/10.1186/s12944-016-0373-6 info:eu-repo/grantAgreement/JA/0269/05 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Fatty acid metabolism Long-chain acyl CoA dehydrogenase Medium-chain acyl CoA dehydrogenase Placenta Obstetricia Obstetrics Tissue specific expression of human fatty acid oxidation enzyme genes in late pregnancy info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/4995/8/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 8 THUMBNAIL Bartha-lhd_ 2016.pdf.jpg Bartha-lhd_ 2016.pdf.jpg IM Thumbnail image/jpeg 4923 https://riubu.ubu.es/bitstream/10259/4995/7/Bartha-lhd_%202016.pdf.jpg c4fa36b9e17d69397e543e21f020a1de MD5 7 ORIGINAL Bartha-lhd_ 2016.pdf Bartha-lhd_ 2016.pdf application/pdf 431887 https://riubu.ubu.es/bitstream/10259/4995/1/Bartha-lhd_%202016.pdf 2ba91e8c2c406b45bc2f3a92e27e44f3 MD5 1 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/4995/5/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 5 TEXT Bartha-lhd_ 2016.pdf.txt Bartha-lhd_ 2016.pdf.txt Extracted text text/plain 24017 https://riubu.ubu.es/bitstream/10259/4995/6/Bartha-lhd_%202016.pdf.txt 8115ee6d5a14b5bec7ff030f29ab5033 MD5 6 10259/4995 oai:riubu.ubu.es:10259/4995 2021-11-10 10:38:26.077 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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