2026-05-14T16:47:29Zhttps://riubu.ubu.es/oai/request
oai:riubu.ubu.es:10259/50412026-02-06T12:55:16Zcom_10259_4363com_10259_5086com_10259_2604com_10259_4365col_10259_4364col_10259_4366
Martínez Alonso, Marta 772 500 0000-0002-0931-5274 Busto Vázquez, Natalia 83 500 0000-0001-9637-1209 Aguirre, Larry Danilo d8f3d0c5-4b0f-4b86-8616-a651dd99211f 500 Berlanga, Leticia 60 600 Carrión, María C. . 4c408705-be64-42af-bf67-5d7589b34ea3 500 Cuevas Vicario, José Vicente 137 500 0000-0002-2421-1529 Rodríguez, Ana M. . 64013be0-a1f8-4eba-8154-e6f7c49a9c55 500 Carbayo Martín, Mª Aránzazu 99 500 0000-0003-4738-4323 Manzano, Blanca R. . 0f83ceaf-9369-470a-a22b-9b5894978fc0 500 Ortí, Enrique . ae054243-d1de-44f9-9c7f-d02346c90393 500 Jalón Sotés, Félix Ángel 83a58ec8-3904-4c18-838c-bcdaf7357757 600 García Ruiz, Begoña 217 500 0000-0002-0817-1651 Espino Ordóñez, Gustavo 162 500 0000-0001-5617-5705 2018-12-04T08:45:55Z 2018-11 2019-11-27 0947-6539 http://hdl.handle.net/10259/5041 10.1002/chem.201803784 In this paper, the synthesis, comprehensive characterization and biological and photocatalytic properties of two series of neutral IrIII biscyclometalated complexes of general formula [Ir(C^N)2(N^O)], where the N^O ligands are 2‐(benzimidazolyl)phenolate‐N,O (L1, series a) and 2‐(benzothiazolyl)phenolate‐N,O (L2, series b), and the C^N ligands are 2‐(phenyl)pyridinate or its derivatives, are described,. Complexes of types a and b exhibit dissimilar photophysical and biological properties. In vitro cytotoxicity tests conclusively prove that derivatives of series a are harmless in the dark against SW480 cancer cells (colon adenocarcinoma), but express enhanced cytotoxicity versus the same cells after stimulation with UV or blue light. In contrast, complexes of type b show a very high cytotoxic activity in the dark, but low photosensitizing ability. Thus, the ancillary N^O ligand is the main factor in terms of cytotoxic activity both in the dark and upon irradiation. However, the C^N ligands play a key role regarding cellular uptake. In particular, the complex of formula [Ir(dfppy)2(L1)] (dfppy=2‐(4,6‐difluorophenyl)pyridinate) [3 a] has been identified as both an efficient photosensitizer for 1O2 generation and a potential agent for photodynamic therapy. These capabilities are probably related to a combination of its notable cellular internalization, remarkable photostability, high photoluminescence quantum yield, and long triplet excited‐state lifetime. Both types of complexes exhibit notable catalytic activity in the photooxidation of thioanisole and S‐containing aminoacids with full selectivity. SpanishMinisteriode Econom&ayCompetitividad-FEDER(CTQ2014-58812-C2-1-Rand CTQ2014-58812-C2-2-R,CTQ2015-70371-REDT,CTQ2015-71353-R,CTQ2015-71154-P,and Unidadde Excelencia Mar&adeMaeztuMDM-2015-0538),the Conseje-r&adeEducacijn-Juntade CastillayLejn-FEDER(BU299A12-1,BU042U16and BU051U16).The Generalitat Valenciana(Prome-teo2016/135),andthe “la Caixa”Foundation(LCF/PR/PR12/11070003) application/pdf eng Wiley-VCH Verlag Chemistry-a european journal. 2018, V. 24, n. 66, p. 17523-17537 https://doi.org/10.1002/chem.201803784 info:eu-repo/grantAgreement/MINECO/CTQ2014-58812-C2-1-R info:eu-repo/grantAgreement/MINECO/CTQ2014-58812-C2-2-R info:eu-repo/grantAgreement/MINECO/CTQ2015-70371-REDT info:eu-repo/grantAgreement/MINECO/CTQ2015-71353-R info:eu-repo/grantAgreement/MINECO/CTQ2015-71154-P info:eu-repo/grantAgreement/MINECO/MDM-2015-0538 info:eu-repo/grantAgreement/JCyL/BU299A12-1 info:eu-repo/grantAgreement/JCyL/BU042U16 info:eu-repo/grantAgreement/JCyL/BU051U16 info:eu-repo/grantAgreement/GVA/Prometeo2016-135 info:eu-repo/grantAgreement/FundaciónLaCaixa/LCF-PR-PR12-11070003 2-arylazoles anticancercomplexes heterolepticneutraliridium(III)complexes phosphorescent complexes photodynamictherapy Química Chemistry Strong influence of the ancillary ligand over the photodynamic anticancer properties of neutral biscyclometalated IrIII complexes bearing 2‐benzoazole‐phenolates info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/openAccess THUMBNAIL Martinez-caej_2018.pdf.jpg Martinez-caej_2018.pdf.jpg IM Thumbnail image/jpeg 3719 https://riubu.ubu.es/bitstream/10259/5041/4/Martinez-caej_2018.pdf.jpg 118cd3c82c1044bbffca2d9f7e6cb5e6 MD5 4 ORIGINAL Martinez-caej_2018.pdf Martinez-caej_2018.pdf application/pdf 1773101 https://riubu.ubu.es/bitstream/10259/5041/1/Martinez-caej_2018.pdf 40c14a34585aa075df32189e01ddd861 MD5 1 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/5041/2/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 2 TEXT Martinez-caej_2018.pdf.txt Martinez-caej_2018.pdf.txt Extracted text text/plain 85560 https://riubu.ubu.es/bitstream/10259/5041/3/Martinez-caej_2018.pdf.txt 5e998097bd60bed165228c56c56db669 MD5 3 10259/5041 oai:riubu.ubu.es:10259/5041 2026-02-06 13:55:16.74 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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