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oai:riubu.ubu.es:10259/50852021-11-10T09:38:27Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597

Burgos López, Y. 3e65d86e-2d29-437b-be82-1d879ddb5356 500 Plá, Julián del 1bd784cb-1600-4952-aa4b-8d9960598a11 500 Balsa, Lucía M. d30c3c8c-dca2-4143-a9ab-8352175d8fff 500 León, Ignacio E. 673276ff-bbee-4327-92be-002533b85470 500 Echeverría, Gustavo A. 2b0d851a-016a-44ac-a770-0d6c895a9477 500 Piro, Oscar Enrique d61bad4c-b7a0-4785-9eee-d1c6c98bbc1c 500 García Tojal, Javier 221 500 Pis Diez, Reinaldo dba891e7-f406-453b-9d51-6d4eb3d488cc 500 González Baró, Ana C. 8193c5ec-ef8e-4c67-bbe5-31596f1fbeb2 500 Parajón Costa, Beatriz S. 7ef5033b-87a2-4ee0-ac53-eddaa2d60800 500 2019-04-29T07:56:06Z 2019-03 2021-03-01 0020-1693 http://hdl.handle.net/10259/5085 10.1016/j.ica.2018.11.039 The new copper complex, [Cu(HL)(OH2)2](NO3), including the tridentate N-acyhydrazone derived from 4-hydroxy-benzohydrazide and 2-hydroxy-3-methoxybenzaldehyde, (H2L), has been synthesized and characterized in the solid state and in solution by spectroscopic (FTIR, Ra, UV–vis, EPR) methods. The results were compared with those obtained for the hydrazone ligand and complemented with computational methods based on DFT. The crystal structure of the complex has been determined by X-ray diffraction. It crystallizes in the triclinic space group with Z = 2. The Cu(II) ion is in a distorted square pyramidal environment, coordinated to a planar HL- anion acting as a tridentate ligand. The 5-fold coordination is completed with two water molecules. It is arranged in the lattice as H-bonded ribbon-like polymers that extends along the [1 2 1] crystal direction. The cytotoxicity of the complex together with that of the H2L ligand and the copper ion were evaluated in vitro against five different human cancer cell lines namely A549 (lung), MG-63 (bone), MCF-7 and MDA-MB-231 (breast) and Jurkat (leukemia). The copper complex inhibits the cell viability in a dose dependent manner with a greater potency than the H2L ligand and the free copper ion displaying even higher antitumor activity than the well-known anticancer metallodrug cisplatin. CONICET (PIP 11220130100651CO and PIP 0034), UNLP (111/X673) and ANPCyT (PICT 2014-2223) of Argentina. Consejería de Educación CyL and FFEDER BU076U16, BU022G18 and Ministerio de Economía y Competitividad CTQ2016-75023-C2-1-P and CTQ2015-70371-REDTMetDrugs Network (Spain) application/pdf eng Elsevier Inorganica Chimica Acta. 2019, V. 487, p. 31-40 https://doi.org/10.1016/j.ica.2018.11.039 info:eu-repo/grantAgreement/JCyL/BU076U16 info:eu-repo/grantAgreement/JCyL/BU022G18 info:eu-repo/grantAgreement/MINECO/CTQ2016-75023-C2-1-P info:eu-repo/grantAgreement/MINECO/CTQ2015-70371-REDTMetDrugs info:eu-repo/grantAgreement/CONICET/PIP 11220130100651CO info:eu-repo/grantAgreement/CONICET/PIP 0034 info:eu-repo/grantAgreement/UNLP/111-X673 info:eu-repo/grantAgreement/ANPCyT/PICT 2014-2223 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Cu(II)-complex Hydrazones Spectroscopy Crystal structure DFT calculations Anticancer activity Química inorgánica Chemistry, Inorganic Synthesis, crystal structure and cytotoxicity assays of a copper(II) nitrate complex with a tridentate ONO acylhydrazone ligand. Spectroscopic and theoretical studies of the complex and its ligand info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/5085/8/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 8 THUMBNAIL Burgos-ica_2019.pdf.jpg Burgos-ica_2019.pdf.jpg IM Thumbnail image/jpeg 4659 https://riubu.ubu.es/bitstream/10259/5085/7/Burgos-ica_2019.pdf.jpg a33b6f2dc02f6594f05d705d7c02c90c MD5 7 ORIGINAL Burgos-ica_2019.pdf Burgos-ica_2019.pdf application/pdf 911742 https://riubu.ubu.es/bitstream/10259/5085/1/Burgos-ica_2019.pdf 518ce5f8c7ef91fa464b96e9d9329cab MD5 1 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/5085/5/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 5 TEXT Burgos-ica_2019.pdf.txt Burgos-ica_2019.pdf.txt Extracted text text/plain 61622 https://riubu.ubu.es/bitstream/10259/5085/6/Burgos-ica_2019.pdf.txt b16625014b2d18be8ade1ffa964f011d MD5 6 10259/5085 oai:riubu.ubu.es:10259/5085 2021-11-10 10:38:27.964 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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