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oai:riubu.ubu.es:10259/51782021-11-10T09:38:24Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

Reductive molybdenum‐catalyzed direct amination of boronic acids with nitro compounds Suarez Pantiga, Samuel Hernández Ruiz, Raquel Virumbrales, Cintia Pedrosa Sáez, María de los Remedios Sanz Díez, Roberto amination boronic acids molybdenum nitro compounds reduction Química orgánica Chemistry, Organic The synthesis of aromatic amines is of utmost importance in a wide range of chemical contexts. We report a direct amination of boronic acids with nitro compounds to yield (hetero)aryl amines. The novel combination of a dioxomolybdenum(VI) catalyst and triphenylphosphine as inexpensive reductant has revealed to be decisive to achieve this new C-N coupling. Our methodology has proven to be scalable, air and moisture tolerant, highly chemoselective and engages both aliphatic and aromatic nitro compounds. More-over, this general and step-economical synthesis of aromatic secondary amines show cases orthogonality to other aromatic secondary amines show cases orthogonality to other aromatic amine syntheses as it tolerates aryl halides and carbonyl compounds. Junta de Castilla y León (BU022G18),Junta de Castilla y León and FEDER (BU076U16 and BU291P18) and Ministerio de Economía y Competitividad (MINECO) (CTQ2016-75023-C2-1-P) 2019-11-13T09:16:22Z 2019-11-13T09:16:22Z 2019-02 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 1433-7851 http://hdl.handle.net/10259/5178 10.1002/anie.201812806 1521-3773 spa Angewandte Chemie International Edition. 2019, V. 58, n. 11, p. 2129-2133 https://doi.org/10.1002/anie.201812806 info:eu-repo/grantAgreement/JCyL/U022G18 info:eu-repo/grantAgreement/JCyL/BU076U16 info:eu-repo/grantAgreement/JCyL/BU291P18 info:eu-repo/grantAgreement/MINECO/CTQ2016-75023-C2-1-P info:eu-repo/semantics/openAccess application/pdf Wiley https://riubu.ubu.es/bitstream/10259/5178/3/Suarez-ach_2019.pdf.jpg Hispana TEXT http://rightsstatements.org/vocab/CNE/1.0/ RIUBU. Repositorio Institucional de la Universidad de Burgos http://hdl.handle.net/10259/5178