2026-04-29T00:13:18Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/52002021-11-10T09:38:27Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597

Rodríguez, María R. de4ee4ea-1aad-4fd7-b28a-22371fc05def 500 Balsa, Lucía M. d30c3c8c-dca2-4143-a9ab-8352175d8fff 500 Plá, Julián del 1bd784cb-1600-4952-aa4b-8d9960598a11 500 García Tojal, Javier 221 500 Pis Diez, Reinaldo dba891e7-f406-453b-9d51-6d4eb3d488cc 500 Parajón Costa, Beatriz S. 7ef5033b-87a2-4ee0-ac53-eddaa2d60800 500 León, Ignacio E. 673276ff-bbee-4327-92be-002533b85470 500 González Baró, Ana C. 8193c5ec-ef8e-4c67-bbe5-31596f1fbeb2 500 2020-01-08T10:10:24Z 2020-01-08T10:10:24Z 2019 1144-0546 http://hdl.handle.net/10259/5200 10.1039/C9NJ02092F 1369-9261 From the interaction of the vanadyl ion with a ligand (HL), obtained by the condensation reaction of o-vanillin and 2-thiophenemethylamine, an oxidovanadium(IV) complex (VOL2) was obtained. It was characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance, and UV-vis and EPR, in solution. Its thermal behavior was analyzed by means of TGA and DTA. Theoretical studies based on DFT computational methods aided in the interpretation and assignment of spectroscopic data. Cytotoxicity assays (48 h) against bone cancer cells (MG-63, IC50 = 50.4 ± 8.7), breast cancer cells (MCF-7, IC50 = 42.3 ± 4.7), (MDA-MB-231, IC50 = 29.0 ± 1.7) and a normal fibroblast (L929, IC50 = 71.0 ± 3.5) demonstrated the enhancement of the effectiveness and selectivity of the complex as compared with both the ligand and the free metal ion. Besides, the compound inhibits cell migration, increases ROS levels and facilitates apoptosis. On a whole, these results show the main mechanisms of the deleterious effects of [VOL2] in a triple negative breast cancer cell line (MDA-MB-231), demonstrating that this complex is a promising therapeutic agent for this kind of breast cancer. CONICET-CCT-La Plata (PIP 0651 and 0034), ANPCyT (PICT 2016-1574) and UNLP (11/X763) Argentina and also by Consejerı´a de Educacio´n CyL and FFEDER BU076U16, BU022G18 and Ministerio de Economı´a y Competitividad CTQ2016-75023-C2-1-P and CTQ2015-70371- REDT MetDrugs Network (Spain) application/pdf eng Royal Society of Chemistry New Journal of Chemistry. 2019, V. 43, n. 29, p. 11784-11794 https://doi.org/10.1039/C9NJ02092F info:eu-repo/grantAgreement/JCyL/BU076U16 info:eu-repo/grantAgreement/JCyL/BU022G18 info:eu-repo/grantAgreement/MINECO/CTQ2016-75023-C2-1-P info:eu-repo/grantAgreement/MINECO/CTQ2015-70371- REDT info:eu-repo/grantAgreement/CONICET-CCT-La Plata/PIP-0651 info:eu-repo/grantAgreement/CONICET-CCT-La Plata/PIP-0034 info:eu-repo/grantAgreement/ANPCyT/PICT 2016-1574 info:eu-repo/grantAgreement/UNLP/11-X763 Química inorgánica Chemistry, Inorganic Synthesis, characterization, DFT calculations and anticancer activity of a new oxidovanadium(iv) complex with a ligand derived from o-vanillin and thiophene info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/openAccess TEXT Rodríguez-njc_2019.pdf.txt Rodríguez-njc_2019.pdf.txt Extracted text text/plain 64146 https://riubu.ubu.es/bitstream/10259/5200/4/Rodr%c3%adguez-njc_2019.pdf.txt a95a63f994de8f43346a743e91c4daa4 MD5 4 THUMBNAIL Rodríguez-njc_2019.pdf.jpg Rodríguez-njc_2019.pdf.jpg IM Thumbnail image/jpeg 4862 https://riubu.ubu.es/bitstream/10259/5200/3/Rodr%c3%adguez-njc_2019.pdf.jpg e9622eb2c287bc671eefaeb506f17d19 MD5 3 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/5200/2/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 2 ORIGINAL Rodríguez-njc_2019.pdf Rodríguez-njc_2019.pdf application/pdf 1929974 https://riubu.ubu.es/bitstream/10259/5200/1/Rodr%c3%adguez-njc_2019.pdf e67c0b1be6bed20560957f8a4609f10f MD5 1 10259/5200 oai:riubu.ubu.es:10259/5200 2021-11-10 10:38:27.919 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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