2026-04-28T23:55:00Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/52012022-05-20T13:22:48Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597
Rodríguez, María R.
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Plá, Julián del
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Balsa, Lucía M.
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León, Ignacio E.
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Piro, Oscar Enrique
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Echeverría, Gustavo A.
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García Tojal, Javier
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Pis Diez, Reinaldo
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Parajón Costa, Beatriz S.
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González Baró, Ana C.
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2020-01-08T12:44:58Z
2020-01-08T12:44:58Z
2019-05
1144-0546
http://hdl.handle.net/10259/5201
10.1039/C8NJ06274A
1369-9261
The interaction of a poly-functional ligand derived from o-vanillin and 2-thiophenemethylamine (oVATPNH2) with transition metal ions Cu(II) and Zn(II) leads to the formation of stable coordination compounds, namely [Cu(oVATPNH2)2] and [Zn(oVATPNH2)2]. Their crystal structures have been determined by X-ray diffraction methods. Two molecules of the deprotonated ligand acting in a bidentate fashion build a nearly square planar environment around Cu(II) and a distorted tetrahedral coordination arrangement for Zn(II). The complexes were characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance and solution UV-vis and EPR. Their thermal behavior has been analyzed by means of TGA and DTA. DFT theoretical studies, using computational methods based on DFT, were employed to assist the interpretation and assignment of spectroscopic data. Cytotoxicity assays against two human breast cancer cell lines, namely MCF-7 and MDA-MB-231, revealed an enhancement of the effectiveness of the complexes as compared with both the ligand and the free metal ions. The results for the copper compound are promising, as its cytotoxic effect was stronger than the reference metallodrug cisplatin in both cancer cell lines tested.
CONICET-CCT-La Plata (PIP 0651 and 0034), ANPCyT (PICT 2016-1574) and UNLP (11/X-473) (Argentina) and also by Consejerı´a de Educacio´n CyL and FFEDER BU076U16, BU022G18 and Ministerio de Economı´a y Competitividad CTQ2016-75023-C2-1-P and CTQ2015-70371- REDT MetDrugs Network (Spain
application/pdf
eng
Royal Society of Chemistry
New Journal of Chemistry. 2019, V. 43, n. 18, p. 7120-7129
https://doi.org/10.1039/C8NJ06274A
info:eu-repo/grantAgreement/CONICET-CCT-La Plata/PIP-0651
info:eu-repo/grantAgreement/CONICET-CCT-La Plata/PIP-0034
info:eu-repo/grantAgreement/ANPCyT/PICT 2016-1574
info:eu-repo/grantAgreement/UNLP/11-X473
info:eu-repo/grantAgreement/MINECO/CTQ2016-75023-C2-1-P
info:eu-repo/grantAgreement/MINECO/CTQ2015-70371- REDT
info:eu-repo/grantAgreement/JCyL/BU076U16
info:eu-repo/grantAgreement/JCyL/BU022G18
Química inorgánica
Chemistry, Inorganic
Cu(ii) and Zn(ii) complexes with a poly-functional ligand derived from o-vanillin and thiophene. Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
info:eu-repo/semantics/openAccess
TEXT
Rodriguez-njc_2019-mayo.pdf.txt
Rodriguez-njc_2019-mayo.pdf.txt
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10259/5201
oai:riubu.ubu.es:10259/5201
2022-05-20 15:22:48.307
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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