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Perdomo Hernández, Germán M. Merino, Beatriz Fernández Díaz, Cristina M. . Cózar Castellano, Irene 2020-03-13T09:13:36Z 2020-03-13T09:13:36Z 2020-01 http://hdl.handle.net/10259/5242 10.3390/nu12010094 2072-6643 The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed. Spanish MINISTERIO DE ECONOMÍA, INDUSTRIA Y COMPETITIVIDAD, grant numbers SAF2016-77871-C2-1-R and SAF2016-77871-C2-2-R to I.C-C. and G.P. respectively; the EFSD European Research Programme on New Targets for Type 2 Diabetes supported by an educational research grant from MSD to I.C-C. and G.P.; the FUNDACIÓN LA-CAIXA Y FUNDACIÓN CAJA DE BURGOS, grant number CAIXA-UBU001 to G.P. application/pdf eng MDPI Nutrients. 2020, V. 12, n. 1, 94 https://doi.org/10.3390/nu12010094 info:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-1-R info:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-2-R info:eu-repo/grantAgreement/FundaciónLaCaixa/CAIXA-UBU001 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess fructose glucose small intestine liver brain gut-brain axis non-alcoholic fatty liver insulin resistance metabolic syndrome type 2 diabetes mellitus Endocrinología Endocrinology Intestinal fructose and glucose metabolism in health and disease info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nutrients 12 1 94