2026-04-28T22:45:39Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/52422021-11-02T12:06:21Zcom_10259_4725com_10259_5086com_10259_2604col_10259_4726

Perdomo Hernández, Germán M. 433 500 Merino, Beatriz 495e29d2-20b6-4c40-bf6a-c80b0c3b2cc5 500 Fernández Díaz, Cristina M. . 85487389-124d-4d58-9144-f9eb09bb9028 500 Cózar Castellano, Irene 3f72cbc3-d322-4e0a-a780-4e0fc4965813 500 2020-03-13T09:13:36Z 2020-03-13T09:13:36Z 2020-01 http://hdl.handle.net/10259/5242 10.3390/nu12010094 2072-6643 The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed. Spanish MINISTERIO DE ECONOMÍA, INDUSTRIA Y COMPETITIVIDAD, grant numbers SAF2016-77871-C2-1-R and SAF2016-77871-C2-2-R to I.C-C. and G.P. respectively; the EFSD European Research Programme on New Targets for Type 2 Diabetes supported by an educational research grant from MSD to I.C-C. and G.P.; the FUNDACIÓN LA-CAIXA Y FUNDACIÓN CAJA DE BURGOS, grant number CAIXA-UBU001 to G.P. application/pdf eng MDPI Nutrients. 2020, V. 12, n. 1, 94 https://doi.org/10.3390/nu12010094 info:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-1-R info:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-2-R info:eu-repo/grantAgreement/FundaciónLaCaixa/CAIXA-UBU001 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess fructose glucose small intestine liver brain gut-brain axis non-alcoholic fatty liver insulin resistance metabolic syndrome type 2 diabetes mellitus Endocrinología Endocrinology Intestinal fructose and glucose metabolism in health and disease info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nutrients 12 1 94 ORIGINAL Merino-nutrients_2020.pdf Merino-nutrients_2020.pdf application/pdf 22722669 https://riubu.ubu.es/bitstream/10259/5242/1/Merino-nutrients_2020.pdf 18cb8bbca4a7d67517544fc7018ea78e MD5 1 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/5242/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/5242/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 THUMBNAIL Merino-nutrients_2020.pdf.jpg Merino-nutrients_2020.pdf.jpg IM Thumbnail image/jpeg 3365 https://riubu.ubu.es/bitstream/10259/5242/4/Merino-nutrients_2020.pdf.jpg a089cb8bbc32260d212f7378560d7c75 MD5 4 TEXT Merino-nutrients_2020.pdf.txt Merino-nutrients_2020.pdf.txt Extracted text text/plain 144609 https://riubu.ubu.es/bitstream/10259/5242/5/Merino-nutrients_2020.pdf.txt 1a0847ecb15925d1c685279607e964a5 MD5 5 10259/5242 oai:riubu.ubu.es:10259/5242 2021-11-02 13:06:21.067 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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