2026-04-28T20:46:54Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/52992022-04-06T13:11:39Zcom_10259_4292com_10259_5086com_10259_2604com_10259.4_2516col_10259_4293col_10259.4_2517

Gerardi, Gisela Cavia Saiz, Mónica Pino García, Raquel del Rivero Pérez, Maria Dolores González San José, Mª Luisa Muñiz Rodríguez, Pilar 2020-05-08T18:42:43Z 2020-05-08T18:42:43Z 2020-03 1756-4646 http://hdl.handle.net/10259/5299 10.1016/j.jff.2020.103794 Vascular remodeling in hypertension and diabetes is characterized by a low-grade inflammation of the arterial wall and enhanced oxidative stress. Wine pomace products attenuate hyperglycemia and hypertension through reduction of oxidative stress and inflammation by their polyphenol composition. The aim of the study was to assess the influence of the wine pomace product (WP) on morphometric parameters of the arterial wall in spontaneously hypertensive rats (SHRs) and streptozotocin-diabetic rats (STZ). Oxidative stress was also evaluated by determination of radical oxygen species (ROS) and endothelial nitric oxide synthase (eNOS) activation in thoracic aortas. Wine pomace reduces wall aortic thickness, cross sectional area and wall/lumen ratio, and decreases ROS and increases eNOS activation. In summary, the supplementation of hypertensive or diabetic rats with the wine pomace product exhibits a protective role against the endothelial dysfunction and vascular remodeling. Autonomous Government of Castilla y León (Research project BU282U13 application/pdf eng Elsevier Journal of Functional Foods.2020, V. 66, 103794 https://doi.org/10.1016/j.jff.2020.103794 info:eu-repo/grantAgreement/JCyL/BU282U13 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Aorta Diabetes Hypertension Vascular remodeling eNOS Wine pomace product Alimentos Bioquímica Biología molecular Food Biochemistry Molecular biology Wine pomace product ameliorates hypertensive and diabetic aorta vascular remodeling through antioxidant and anti-inflammatory actions info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Journal of Functional Foods 66 103794