2026-04-28T22:11:23Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/52992022-04-06T13:11:39Zcom_10259_4292com_10259_5086com_10259_2604com_10259.4_2516col_10259_4293col_10259.4_2517

00925njm 22002777a 4500 dc Gerardi, Gisela author Cavia Saiz, Mónica author Pino García, Raquel del author Rivero Pérez, Maria Dolores author González San José, Mª Luisa author Muñiz Rodríguez, Pilar author 2020-03 Vascular remodeling in hypertension and diabetes is characterized by a low-grade inflammation of the arterial wall and enhanced oxidative stress. Wine pomace products attenuate hyperglycemia and hypertension through reduction of oxidative stress and inflammation by their polyphenol composition. The aim of the study was to assess the influence of the wine pomace product (WP) on morphometric parameters of the arterial wall in spontaneously hypertensive rats (SHRs) and streptozotocin-diabetic rats (STZ). Oxidative stress was also evaluated by determination of radical oxygen species (ROS) and endothelial nitric oxide synthase (eNOS) activation in thoracic aortas. Wine pomace reduces wall aortic thickness, cross sectional area and wall/lumen ratio, and decreases ROS and increases eNOS activation. In summary, the supplementation of hypertensive or diabetic rats with the wine pomace product exhibits a protective role against the endothelial dysfunction and vascular remodeling. 1756-4646 http://hdl.handle.net/10259/5299 10.1016/j.jff.2020.103794 Aorta Diabetes Hypertension Vascular remodeling eNOS Wine pomace product Wine pomace product ameliorates hypertensive and diabetic aorta vascular remodeling through antioxidant and anti-inflammatory actions