2026-04-28T20:46:45Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/52992022-04-06T13:11:39Zcom_10259_4292com_10259_5086com_10259_2604com_10259.4_2516col_10259_4293col_10259.4_2517
Repositorio Institucional de la Universidad de Burgos
author
Gerardi, Gisela
author
Cavia Saiz, Mónica
author
Pino García, Raquel del
author
Rivero Pérez, Maria Dolores
author
González San José, Mª Luisa
author
Muñiz Rodríguez, Pilar
2020-05-08T18:42:43Z
2020-05-08T18:42:43Z
2020-03
1756-4646
http://hdl.handle.net/10259/5299
10.1016/j.jff.2020.103794
Vascular remodeling in hypertension and diabetes is characterized by a low-grade inflammation of the arterial wall and enhanced oxidative stress. Wine pomace products attenuate hyperglycemia and hypertension through reduction of oxidative stress and inflammation by their polyphenol composition. The aim of the study was to assess the influence of the wine pomace product (WP) on morphometric parameters of the arterial wall in spontaneously hypertensive rats (SHRs) and streptozotocin-diabetic rats (STZ). Oxidative stress was also evaluated by determination of radical oxygen species (ROS) and endothelial nitric oxide synthase (eNOS) activation in thoracic aortas. Wine pomace reduces wall aortic thickness, cross sectional area and wall/lumen ratio, and decreases ROS and increases eNOS activation. In summary, the supplementation of hypertensive or diabetic rats with the wine pomace product exhibits a protective role against the endothelial dysfunction and vascular remodeling.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aorta
Diabetes
Hypertension
Vascular remodeling
eNOS
Wine pomace product
Wine pomace product ameliorates hypertensive and diabetic aorta vascular remodeling through antioxidant and anti-inflammatory actions
info:eu-repo/semantics/article
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