2026-04-28T15:43:56Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/53182022-05-30T22:42:07Zcom_10259_3596com_10259_5086com_10259_2604com_10259_4292col_10259_3597col_10259_4293

Alcaraz, Raquel f37b3220-2c62-4524-ab2c-60d6a8de878a 500 Muñiz Rodríguez, Pilar 380 500 Cavia Saiz, Mónica 116 500 Palacios, Óscar 09f1f1aa-f24e-4d4c-889c-b2db8c13dee7 500 Samper, Katia G. a5503711-3831-4506-8666-df7d13758a9e 500 Gil García, Rubén 232 500 Jiménez Pérez, Alondra 8c2196b9-9c59-46e2-8876-b19d7ed12249 500 García Tojal, Javier 221 500 García Girón, Carlos a191a584-8644-4b54-b047-affd824c0493 500 2020-06-01T15:15:44Z 2020-06-01T15:15:44Z 2020-05 0162-0134 http://hdl.handle.net/10259/5318 10.1016/j.jinorgbio.2020.110993 Colorectal cancer is the third most common type of cancer and has a high incidence in developed countries. At present, specific treatments are being required to allow individualized therapy depending on the molecular alteration on which the drug may act. The aim of this project is to evaluate whether HPTSC and HPTSC* thiosemicarbazones (HPTSC = pyridine-2-carbaldehyde thiosemicarbazone and HPTSC* = pyridine-2-carbaldehyde 4N-methylthiosemicarbazone), and their complexes with different transition metal ions as Cu(II), Fe(III) and Co(III), have antitumor activity in colon cancer cells (HT-29 and SW-480), that have different oncogenic characteristics. Cytotoxicity was evaluated and the involvement of oxidative stress in its mechanism of action was analyzed by quantifying the superoxide dismutase activity, redox state by quantification of the thioredoxin levels and reduced/oxidized glutathione rate and biomolecules damage. The apoptotic effect was evaluated by measurements of the levels of caspase 9 and 3 and the index of histones. All the metal-thiosemicarbazones have antitumor activity mediated by oxidative stress. The HPTSC*-Cu was the compound that showed the best antitumor and apoptotic characteristics for the cell line SW480, that is KRAS gene mutated. application/pdf eng Elsevier Journal of Inorganic Biochemistry. 2020, V. 206, 110993 https://doi.org/10.1016/j.jinorgbio.2020.110993 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Cell death Cobalt compounds Colon carcinoma Iron compounds Oxidative stress Thiosemicarbazone Bioquímica Biochemistry Thiosemicarbazone-metal complexes exhibiting cytotoxicity in colon cancer cell lines through oxidative stress info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Journal of Inorganic Biochemistry 206 110993 TEXT Alcaraz-jib_2020.pdf.txt Alcaraz-jib_2020.pdf.txt Extracted text text/plain 78976 https://riubu.ubu.es/bitstream/10259/5318/5/Alcaraz-jib_2020.pdf.txt 02f68dce1f4c2192332a3137f0ad7bb9 MD5 5 THUMBNAIL Alcaraz-jib_2020.pdf.jpg Alcaraz-jib_2020.pdf.jpg IM Thumbnail image/jpeg 4472 https://riubu.ubu.es/bitstream/10259/5318/4/Alcaraz-jib_2020.pdf.jpg df9ae8f97da4e9fbfa4ed76ccd2efebc MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 999 https://riubu.ubu.es/bitstream/10259/5318/3/license.txt b295bcbce42e2caabeb0c623d3860c06 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/5318/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Alcaraz-jib_2020.pdf Alcaraz-jib_2020.pdf application/pdf 1205030 https://riubu.ubu.es/bitstream/10259/5318/1/Alcaraz-jib_2020.pdf 06db0b089e59101f05fbc4c961711c6a MD5 1 10259/5318 oai:riubu.ubu.es:10259/5318 2022-05-31 00:42:07.808 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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