2026-04-28T12:44:29Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/53702021-11-02T12:01:31Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925
Soto Cerrato, Vanessa
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Manuel Manresa, Pilar .
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Hernando Santa Cruz, Elsa
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Calabuig Fariñas, Silvia
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Martínez Romero, Alicia
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500
Fernández Dueñas, Víctor
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500
Sahlholm, Kristoffer
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500
Knöpfel, Thomas
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García Valverde, María
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Rodilla, Ananda M.
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Jantus Lewintre, Eloisa
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Farràs, Rosa
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Ciruela, Francisco
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Pérez Tomás, Ricardo
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Quesada Pato, Roberto
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2020-07-10T09:36:52Z
2020-07-10T09:36:52Z
2015-12
0002-7863
http://hdl.handle.net/10259/5370
10.1021/jacs.5b09970
1520-5126
Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation.
panishgovernment and the EU (FIS PI13/00089, FIS PI12/02838,FIS PI12/00956 and RD12/0036/0025), a grant from LaMaratóde TV3 Foundation (20132730), a grant from SEPAR(17/2014), Consejería de Educación de la Junta de Castilla yLeón (Project BU340U13), Ministerio de Economíaycompetitividad/Instituto de Salud Carlos III (SAF2014-55700-P), and ICREA Academia-2010
application/pdf
eng
American Chemical Society
Journal of the American Chemical Society. 2015, V. 137, n. 50, p. 15892-15898
https://doi.org/10.1021/jacs.5b09970
Química orgánica
Chemistry, Organic
Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
info:eu-repo/semantics/openAccess
Journal of the American Chemical Society
137
50
15892
15898
ORIGINAL
Soto-jacs_2015.pdf
Soto-jacs_2015.pdf
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2020431
https://riubu.ubu.es/bitstream/10259/5370/1/Soto-jacs_2015.pdf
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LICENSE
license.txt
license.txt
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https://riubu.ubu.es/bitstream/10259/5370/2/license.txt
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THUMBNAIL
Soto-jacs_2015.pdf.jpg
Soto-jacs_2015.pdf.jpg
IM Thumbnail
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https://riubu.ubu.es/bitstream/10259/5370/3/Soto-jacs_2015.pdf.jpg
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TEXT
Soto-jacs_2015.pdf.txt
Soto-jacs_2015.pdf.txt
Extracted text
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https://riubu.ubu.es/bitstream/10259/5370/4/Soto-jacs_2015.pdf.txt
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10259/5370
oai:riubu.ubu.es:10259/5370
2021-11-02 13:01:31.884
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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