2026-04-17T12:24:09Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/55342021-11-02T12:05:28Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

00925njm 22002777a 4500 dc Sedano Labrador, Carlos author Velasco, Rocío author Feberero, Claudia author Suarez Pantiga, Samuel author Sanz Díez, Roberto author 2020-08 The α-lithiobenzyloxy group, easily generated from aryl benzyl ethers by selective α-lithiation with t-BuLi at low temperature, behaves as a directed metalation group (DMG) providing a direct access to o-lithiophenyl α-lithiobenzyl ethers. This ortho-directing effect is reinforced in substrates bearing an additional methoxy group at the meta position. The generated dianions can be reacted with a selection of electrophiles including carboxylic esters and dihalosilanes or germanes, which afford interesting benzofuran, sila(germa)dihydrobenzofuran, and silachroman derivatives from simple aryl benzyl ethers. 1523-7060 http://hdl.handle.net/10259/5534 10.1021/acs.orglett.0c02199 1523-7052 Functionalization Ethers Rearrangement Reaction products Pharmaceuticals α-Lithiobenzyloxy as a Directed Metalation Group in ortho-Lithiation Reactions