2026-04-29T20:03:36Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/58172022-05-20T13:23:36Zcom_10259_4141com_10259_5086com_10259_2604com_10259.4_2516col_10259_4142col_10259.4_2517

Can plasma α-Synuclein help us to differentiate parkinson’s disease from essential tremor? Albillos García, Silvia María Montero, Olimpio Calvo Meruelo, Sara Solano, Berta Trejo Gabriel y Galán, José Mª Cubo Delgado, Esther Parkinson’s disease Essential tremor alpha-synuclein plasma biomarker diagnosis Bioquímica Biología molecular Biochemistry Molecular biology Background: Studies have revealed controversial results regarding the diagnostic accuracy of plasma α-synuclein levels in patients with Parkinson’s disease (PD). This study was aimed to analyze the diagnostic accuracy of plasma α-synuclein in PD versus healthy controls and patients with essential tremor (ET). Methods: In this cross-sectional study, we included de novo (n = 19) and advanced PD patients [OFF (n = 33), and On (n = 35) states], patients with ET (n = 19), and controls (n = 35). The total plasma α-synuclein levels were determined using an ELISA sandwich method. We performed adjusted multivariate regression analysis to estimate the association of α-synuclein levels with group conditions [controls, ET, and de novo, OFF and ON-PD]. We studied the diagnostic accuracy of plasma α-synuclein using the area under the curve (AUC). Results: The plasma α-synuclein levels were higher in controls compared to PD and ET (p < 0.0001), discriminating de novo PD from controls (AUC = 0.74, 95% CI 0.60–0.89), with a trend towards in advanced PD (OFF state) from ET (AUC = 0.69, 95% CI 0.53–0.84). Conclusions: This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary findings suggest that plasma α-synuclein levels might help to discriminate de novo and advanced PD from controls and ET. Junta de Castilla y León is acknowledged for funding through the Biomedicine open project call (Ref. BIO/BU06/14) 2021-06-28T09:38:03Z 2021-06-28T09:38:03Z 2021-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/10259/5817 10.5334/tohm.600 2160-8288 eng Tremor and Other Hyperkinetic Movements. 2021, V. 11, n. 1: 20, pp. 1–8. https://doi.org/10.5334/tohm.600 info:eu-repo/grantAgreement/JCyL/BIO/BU06/14 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Ubiquity Press